Kids' Health Commonly Prescribed Drugs 30 Most Commonly Prescribed Children’s Medications Most Prescribed Drugs for Kids and Teens By Vincent Iannelli, MD Updated on April 18, 2024 Medically reviewed by Jonathan B. Jassey, DO Print This list of the most prescribed drugs for children and teens can help you understand the medicines your pediatrician may recommend for your kids. In a study of pediatric medicine trends over an eight year period, antibiotics were prescribed the most for kids. However, this declined over time and prescriptions for attention-deficit hyperactivity disorder increased. This article explores the most common prescription medications for children and teens. It will also explain the concerns that each medication may treat. 1 Amoxicillin Antoine Arraou / Getty Images This medication is a commonly prescribed antibiotic for kids. Amoxil (amoxicillin) is typically inexpensive and is generally well tolerated. It may be used to treat bacterial infections such as strep throat, childhood pneumonia, ear infections, and sinus infections. 2 Azithromycin Zithromax (azithromycin) is available as a generic antibiotic and may be referred to as a Z-PAK. It is often prescribed for ear infections. 3 Albuterol Albuterol is a type of medication used to help with asthma and other breathing issues. It is available as a nebulizer, which turns medicine into a mist that you breathe in. It is also available as a metered dose inhaler, which outputs a specific amount of medicine. The syrup form of albuterol is rarely used. Albuterol nebulizer solution is an inexpensive medication. Albuterol asthma inhalers tend to be more expensive. However, there is a Ventolin HFA inhaler that tends to be a less expensive inhaler option. 4 Amoxicillin/Clavulanate Augmentin combines amoxicillin and clavulanate, which helps overcome resistant bacteria. It is commonly used to treat ear infections, sinus infections, pneumonia, infected bites, and oral infections. 5 Cefdinir Omnicef (cefdinir) is a type of antibiotic called a cephalosporin that is commonly used to treat sinus infections, ear infections, and pneumonia. Cefdinir is not usually considered to be a first-line treatment. In general, cefdinir is a little more expensive than some other antibiotics. 6 Cephalexin Keflex (cephalexin) is an antibiotic used to treat bacterial infections including: Strep throat Pneumonia Cellulitis, a bacterial infection in deeper layers of the skin Impetigo, a skin infection that causes sores Bone and joint infections It is available as an inexpensive generic. 7 Fluticasone Fluticasone is a steroid that is the main ingredient in many different medications including: Generic Flonase nasal spray, an allergy medicationFluticasone inhalers, medications that help with asthmaGeneric Cutivate cream and ointment, the only FDA-approved topical steroid treatment for children experiencing itchy skin Some medications contain fluticasone combined with another active ingredient. Flovent was a common inhaler for asthma that contained only fluticasone, but that brand name is no longer available (authorized generics are available). These medications may be used to treat kids with conditions like eczema, allergies, and asthma. 8 Prednisolone Sodium Phosphate Available in both a 25 milligram/5 milliliter and 15 milligram/5 milliliter syrup, prednisolone is a liquid steroid that is commonly used to treat inflammatory conditions like: Asthma Poison ivy reactions Croup, a barking cough caused by throat swelling 9 Ibuprofen Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is commonly used to treat fever, pain, and inflammation in children. Although available over the counter as Motrin and Advil, there are also prescription-strength formulations of it. 10 Singulair (Montelukast Sodium) Singulair (montelukast sodium) is available as a generic and is approved to prevent and treat: Asthma, including exercise-induced asthma Seasonal allergies Year-round allergies 11 Trimethoprim/Sulfamethoxazole Bactrim or Septra (trimethoprim/sulfamethoxazole) is an antibiotic that is most commonly used to treat urinary tract infections, which are infections in the kidney, bladder, and/or urethra. It is also used to treat community-acquired methicillin-resistant Staphylococcus aureus infections (MRSA), which are often skin infections. However, clindamycin may be a more effective option for children. 12 Tylenol #3 Tylenol #3 (codeine phosphate/acetaminophen) is a narcotic pain reliever with Tylenol (acetaminophen). The FDA warns that codeine should only be used when the benefits will outweigh the risks. Some risks include unusual sleepiness, confusion, and shallow breathing. 13 Vicodin Under the brand names of Vicodin, Lortab, and Norco, hydrocodone bitartrate/acetaminophen is a narcotic pain reliever with Tylenol (acetaminophen). It is stronger than codeine. 14 Mupirocin Bactroban (mupirocin) is a topical antibiotic that is often prescribed to treat bacterial skin infections, such as impetigo. Although mupirocin cream and ointment are both available as generics, the ointment tends to be less expensive. 15 Nystatin Some parents may be familiar with Nystatin, an antifungal medication that is used to treat yeast infections, including thrush and candidal diaper rashes. 16 Methylphenidate Methylphenidate is the generic name for a class of stimulants that are used to treat children with attention-deficit/hyperactivity disorder (ADHD). Medications include Ritalin, Concerta, Daytrana, Methylin, and Metadate. Prices for methylphenidate products can vary. 17 Cough and Cold Combinations Dextromethorphan/phenylephrine/chlorpheniramine is a combination cough and cold medication, with: A cough suppressant, which blocks the urge to coughA decongestant, which decreases airway swelling so it's easier to breatheAn antihistamine, which helps with allergy symptoms Keep in mind that experts warn against using these types of cough and cold medicines in children under the age of 6. Instead, try to use age-appropriate medicines that target your child's symptoms. Be aware that in 2023, an FDA panel concluded that oral phenylephrine isn't an effective decongestant. Some retailers have started pulling single-ingredient phenylephrine products from their shelves. 18 Mometasone Mometasone is a corticosteroid used for allergies. It is the active ingredient in: Nasonex nasal spray, which is used to treat seasonal and year-round allergiesElocon cream and ointment, which is used to treat skin conditions like eczema and psoriasisAsmanex Twisthaler, which is used to treat asthma 19 Triamcinolone Another steroid, triamcinolone is the active ingredient in: Nasacort AQ nasal spray, which is used to treat seasonal allergies and is available as a generic and over-the-counter medicineTriamcinolone acetonide cream and ointment, which is used to treat eczema flares and other skin rashes 20 Prednisone Prednisone is used to treat a number of inflammatory conditions in children, such as asthma, poison ivy reactions, and croup. It is commonly used in small dosages for short periods of time. 21 Sodium Fluoride For children who don't have access to tap water with the mineral fluoride in it, fluoride supplements can be an important way to keep their teeth healthy and prevent dental cavities. 22 Multivitamins With Fluoride If needed, children can take a multivitamin with fluoride. In addition to fluoride, these may include iron, as well as vitamin A, D, and C. 23 Amphetamine/Dextroamphetamine Adderall and Adderall XR are the brand names for this type of stimulant used to treat ADHD. Generic versions of intermediate-release Adderall and extended-release Adderall XR are available. 24 Hydrocortisone Hydrocortisone is a low-strength topical steroid that is available as an ointment, cream, lotion, and gel. It is used to treat skin rashes, bites, and stings. 25 Budesonide Budesonide is a steroid that is available as Pulmicort Respules (generic), Pulmicort Flexhaler, and Rhinocort nasal spray. Rhinocort nasal spray is available over the counter. Budesonide is used to treat seasonal allergies, asthma, and other inflammatory conditions. 26 Ciprofloxacin/Dexamethasone Ciprodex is the brand name for this antibiotic/steroid combination. It is often used to treat swimmer's ear and middle ear infections in kids with a perforated eardrum or ear tubes. 27 Promethazine Available as suppositories, tablets, and as a syrup, Phenergan (promethazine) can be used to help with nausea and vomiting. Phenergan has a boxed warning as it can slow breathing and lead to death in children ages 2 and younger. This has led some pediatricians to prescribe Zofran instead. 28 Prednisolone Prednisolone is a liquid steroid that is commonly used to treat asthma flare-ups, eye irritation, poison ivy reactions, croup, and other inflammatory conditions. 29 Antipyrine/Benzocaine Also called A/B otic drops, these ear drops can help with the pain and discomfort that may accompany an ear infection. Not FDA-Approved Most A/B otic drops were not FDA-approved and the FDA announced enforcement actions against manufacturers in 2015 in order to keep the public safe. 30 Lisdexamfetamine Vyvanse (lisdexamfetamine) is the brand name for this stimulant that is used to treat ADHD. It is not available as a generic. Summary Knowing about the most commonly prescribed children's medications may help you if your child is given a prescription. Be sure to mention if your child has any allergies or sensitivities when speaking with their pediatrician. 11 Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Chai G, Governale L, Mcmahon AW, Trinidad JP, Staffa J, Murphy D. Trends of outpatient prescription drug utilization in US children, 2002-2010. Pediatrics. 2012;130(1):23-31. doi:10.1542/peds.2011-2879 Ginsburg A, Mvalo T, Nkwopara E. Placebo vs amoxicillin for nonsevere fast-breathing pneumonia in Malawian children aged 2 to 59 months. JAMA Ped. 2019 Jan;173(1):21-28. doi:10.1001/jamapediatrics.2018.3407 Centers for Disease Control and Prevention. Pediatric outpatient treatment recommendations. Food and Drug Administration. Keflex®. Campbell A, Dotel R, Braddick M, et al. Clindamycin adjunctive therapy for severe Staphylococcus aureus treatment evaluation (CASSETTE)—an open-labelled pilot randomized controlled trial. JAC-AMR. 2022 Feb;4(1):109. doi:10.1093/jacamr/dlac014 Lowry J, Leeder J. Over-the-counter medications: update on cough and cold preparations. Pediatr Rev. 2015;36(7):286-298. doi:10.1542/pir.36-7-286 Food and Drug Administration. FDA clarifies results of recent advisory committee meeting on oral phenylephrine. Jullien S. Prophylaxis of caries with fluoride for children under five years. BMC Pediatr. 2021 Sep;21(1):351. doi:10.1186/s12887-021-02702-3 Rosenfeld R, Schwartz S, Robertson P, et al. Clinical practice guideline: Acute otitis externa. OHNS. 2014 Feb;150(1):1-24. doi:10.1177/0194599813517083 Coté C, Wilson S. Guidelines for monitoring and management of pediatric patients before, during, and after sedation diagnostic and therapeutic procedures. Pediatr. 2019 Jun;143(6):1-31. doi:10.1542/peds.2019-1000 Food and Drug Administration. Use only approved prescription ear drops. By Vincent Iannelli, MD Vincent Iannelli, MD, is a board-certified pediatrician and fellow of the American Academy of Pediatrics. Dr. Iannelli has cared for children for more than 20 years. See Our Editorial Process Meet Our Medical Expert Board Share Feedback Was this page helpful? Thanks for your feedback! What is your feedback? Other Helpful Report an Error Submit