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Zofran for Vomiting

Expert Pediatrics Q&A


Updated May 16, 2014

A girl who cared by Grandma is taking pills in bed
Michael H/Digital Vision/Getty Images
Updated May 16, 2014
Q. My son was recently in the ER because he was vomiting and getting dehydrated and they gave him a dose of Zofran. It seemed to help, but I was surprised that he didn't get Phenergan, like my other child did when he had a bad episode of vomiting last year. And then when I looked up Zofran when i got home, I learned that it was only approved for preventing nausea and vomiting after chemotherapy. So why did my toddler get it when he just had the stomach flu? Tammy, Phoenix, Arizona

A. There are a few good reasons why your child got Zofran (ondansetron) instead of Phenergan. For one thing, there was a big warning from the FDA last year that recommended that Phenergan not be used for children under age two. That warning has made many doctors hesitant to use Phenergan in young children and most won't use it in children under age two anymore. Even in older children, Phenergan so often causes drowsiness, that many Pediatricians don't like to use it. Remember that even if your child isn't vomiting, if he is too sleepy to drink when he has a stomach virus, then he will likely still become dehydrated.

But why use Zofran for the stomach flu? Although Zofran is only approved for preventing nausea and vomiting for patients about to undergo chemotherapy or surgery, many medications are used off-label for other uses. And in this case, there are many research studies that show that Zofran can be helpful for treating and preventing vomiting associated with gastroenteritis or the 'stomach flu.'

In one study, Zofran 'was effective in lowering the rates of intravenous fluid administration and hospital admission in patients with vomiting from acute gastroenteritis.'1

Another study showed that children with gastroenteritis, some as young as 6 months old, given Zofran were less likely to need an IV and spent less time in the ER than children who were given a placebo.2

If it is so helpful in the ER at preventing and treating vomiting from gastroenteritis, how come your Pediatrician isn't very likely to prescribe Zofran at an office visit? For one thing, there are no research studies supporting that it works in this situation. All of the studies have been done in an ER setting. And Zofran is very expensive, with one tablet costing over $20. New generic versions of the Orally Disintegrating Tablet form of Zofran will hopefully make it more affordable and if research supports it, maybe doctors will use it more for kids with the stomach flu.

Even considering the full price of Zofran, when compared to the cost of a hospital admission or even a visit to the ER, the cost of Zofran may be worth it though. Another study did show that Zofran reduced 'the need for admission in those who are treated at an initial visit to the emergency department.'3

Keep in mind that most of the current practice guidelines, including those from the American Academy of Pediatrics, don't recommend using medications to stop vomiting.


1A randomized clinical trial comparing oral ondansetron with placebo in children with vomiting from acute gastroenteritis. Ramsook C - Ann Emerg Med - 01-APR-2002; 39(4): 397-403
2Oral ondansetron useful for gastroenteritis in pediatric ER. N Engl J Med 2006;354:1698-1705.
3Ondansetron Decreases Vomiting Associated With Acute Gastroenteritis: A Randomized, Controlled Trial. PEDIATRICS Vol. 109 No. 4 April 2002, pp. e62

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