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Vincent Iannelli, M.D.

Singulair Side Effects - Hype or Hazard?

By March 28, 2008

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The Food and Drug Administration issued an 'early communication' yesterday that they were "investigating a possible association between the use of Singulair and behavior/mood changes, suicidality (suicidal thinking and behavior) and suicide."

It is important to note that this 'early communication' is not any kind of alert or warning and that no link has yet been found between Singulair and suicide. Instead, as with all medicines, the FDA tries to trace back reports of problems that people have while they take a medicine to see if they are actually caused by the medicine or are just a coincidence. The report on Singulair should be done in about 9 months.

While your kids don't need to stop taking Singulair for their allergies or asthma, it is a good reminder to monitor them for any new symptoms or problems that they develop once they start taking Singulair or any other medicine. And then report those problems or side effects to your pediatrician and the FDA through the Medwatch Reporting System.

Related:
FDA Early Communication About an Ongoing Safety Review of Montelukast (Singulair)
Medwatch - Reporting Medication Side Effects
Allergies
Asthma

Comments
March 29, 2008 at 6:36 pm
(1) Sam says:

What then exactly is the value of the FDA releasing this kind of news release. You’re saying this represents nothing solid and no alert is being issued. Why create angst and indecision about what to do. This is just another example of the incredible incompetence of government.

March 29, 2008 at 7:08 pm
(2) Vincent Iannelli, MD says:

What then exactly is the value of the FDA releasing this kind of news release?

Despite the danger that the news media will make more of it then it is (which they did), there is value in that it may bring more people to report mood changes and even suicides that could be associated with Singulair that they may not have thought about before.

March 29, 2008 at 10:02 pm
(3) concerned parent says:

I had my child on singulair and took him off over three years ago because I noticed changes in him. It seemed to be the “wonder drug for his asthma” but I did notice severe mood changes. I recall mentioning this to his pediatrician. They pretty much discounted this. I also thought it upset his stomach as well. I still notice mood swings. This makes me very sad. I am sure more parents will speak up.

April 1, 2008 at 1:35 pm
(4) Midwest says:

Our son began taking Singulair and Allegra 4 years ago for severe allergies. Within a month he began treatment for panic attacks and for 4 years now has tried to go off his anti-anxiety meds but keeps having panic; (racing heart, respiration). NOW we see the correlation between the timing off the allergy medicines and the panic attacks. I’m sorry to say it never occurred to us before. We have called him at college and said “Get off the Singulair!” It’s worth a try!

April 1, 2008 at 3:01 pm
(5) faye washington says:

my grandchild has only one lung and has been on this med for 8 yrs and now he has bad mood swings and stomach pains he just goes crazy i need some help he is 11 yrs old

April 2, 2008 at 12:33 am
(6) previous singulair user says:

I was on Singulair for asthma and allergies as a college student. I noticed that I started getting migraines as well as severe pupil dilation. I then had to get an EGD for stomach pain and had insomnia as well anxiety and depression. I went off the Singulair, strongly suggested by my mother who correlated the timing of these new symptoms with the new use of Singulair. I tried going off of it and within three months had NONE of these symptoms. I think it is a terrible and dangerous drug that should be taken off of the market!

April 2, 2008 at 8:48 am
(7) Jen says:

My 5 year old was on Singulair for 6 months. He immediately turned into an uncontrollable child. He hated himself, everyone around him, and he would scream that he just wanted to die. There are no words that can express the pain my family and I went through while he was on it. A month ago, my husband found this site http://www.medications.com/se/singulair and we took our son off immediately! It’s been a month now since we took him off and he is 100% back to normal again…our sweet loving, compassionate boy has returned to us. People have been complaining of these side effects since 2003! Why hasn’t anyone listened? My son was almost diagnosed with Autism for gosh sake! Children are being put on the “fast track” with Ritalin or other mood enhancing drugs because of the side effects of this poisonous drug.
Yes, it did keep his asthma at bay, but I’d hate to think of what he would have done if he was older and actually knew what killing himself meant!
Take note, my story happened before the “news” broke on the Singulair/Suicide link.

June 1, 2011 at 3:34 pm
(8) Bridget says:

My son is 5 also and was on this for about 3 weeks. Same horrible side effects you listed,became aggressive,depressed, angry,never listened, hated himself and any failure (at a game or any attempted action). My husband and I were in tears and I was wondering how to find a good child shrink when I googled “Singulair personality changes” and the rest is history.He never had another dose and we have our son back. This stuff should IMO, be taken off the market or if they consider it worth the risk, patients on this drug should be monitored with the same vigilence as Ritalin or Lithium or any other powerful pyschotropic drug, because that’s what Singulair acts like, whether or not it’s the intended use.

August 24, 2011 at 10:26 pm
(9) Lena says:

There is the FDA Med Watch form that you all can fill out and send to them of the adverse side effects that Singular has in children. It is a prepaid postage form and if you feel uncomfortable with filling it out, it will not ask for your child’s name etc.

I JUST pulled my 6 yr old off this medication and should have done this much sooner and surprised that my pediatrician or pediatric asthma/allergy specialist did not even take the time to forewarn me of the serious & complicated side effects.

Whatever is in this medication, it should be treated as Dangerous – my daughter experienced the similar adverse side effects – bad dreams, thoughts of how bad she is, etc. TG, I have my child back, who is returning to some type of normalcy. This weaning period of this drug, now going on (1) week has proven that this medication is not meant for anyone, especially children. Report these bad side effects to the FDA!

June 3, 2011 at 9:15 pm
(10) liz smith says:

OMG!!!!thank you so much for postingyour add on singular. I have twin boys that are 4. One of which has been on the Singular for 2 years/ The babaies only weighed 1 pound at birth and were 4 months early. This meidcation seemed to solve all breathing issues as well as sinus issues. Recently he has threatened to jump over the blacony of stairs in our home to the basement level which would probably kill him or severly wound him. He tells me and his preschool teachers he hates us. He kicks hits and punches other kids and the teacher. No amount of dicipline has worked. He is so out of control I have cried endlessly trying to figure out what has gone wrong int he last 3-6 months. I am thouroughly convinced after reading all the ads its this medication. I stopped the Singualr immediatley and called the Pulminoligst who informed me it takes severl weeks to exit the body. She then stated if this doesnt work he may have to see a behavioral specialist! I am appauled that no one iis really taking a forward stance on this medication and its danger!!!!!!!My God all I can do now is pray there are no life long problems . I have also take n the other twin off the medication as he seems to be develeoping some odd ourbursts and crying and nightmares ont he medication. THANK YOu for speaking out.

June 20, 2011 at 1:26 am
(11) Amber says:

I wish I would have seen this site before putting my daughter on this medication! I cannot believe they prescribe this, I just want to cry it’s like it changed my sweet baby into some kind of demon. The bad dreams stomach pains, aggravated moody sad, depressed. I definitely think this should be taken off the market

April 2, 2008 at 9:41 am
(12) Amy says:

My daughter has been on Singulair for 5 years and has not had any difficulty with the side effects that others are describing. It has been a wonder drug for her and her asthma/allergy symptoms. She could be the poster child for Singulair and how it has worked. It is very sad and very scary that others have had a very different and such a different and horrible experience with it. I hope that the warning has helped some realize why their children have had such an adverse change in behavior and now can do something about it. I don’t think that the FDA overreacted; but I also hope they don’t react further and say that this medication is not safe for anyone and the risks outweigh any benefits-unless they can prove it. Everyone should always read the warning labels and decide if the benefits outweigh the risks and not put themselves in danger because a Dr. made the decision this is what will be best for you.

April 2, 2008 at 9:42 am
(13) Vincent Iannelli, MD says:

[i]People have been complaining of these side effects since 2003![/i]

Yes, the package insert has warned that some children might have some problems with “drowsiness, irritability, agitation including aggressive behavior, restlessness, insomnia,” etc. since 2005. That made it a good resource to look to if a child began to have any new symptoms after taking Singulair to see if could be related to the medication.

It is important to remember that almost any medicine can cause significant side effects for certain children, and if your doctor doesn’t connect the dots, you should ask if there could be a relationship between the new medicine and the new symptoms. There are even some children who get irritable and aggressive when taking Amoxil, which is considered a safe and well tolerated antibiotic.

I’ve had a few younger kids in my practice who developed a change in behavior after starting Singulair, and they quickly got back to their usual behavior after stopping it.

The problem is that since so many other kids don’t have problems with Singulair (and many kids have behavior problems who aren’t taking Singulair), it is easy to dismiss the medication as the cause of a child’s symptoms, which can lead them to continue to take it for months or years and continue to have the side effect unnecessarily.

Being in the news lately should raise awareness and prevent this from happening any longer.

April 2, 2008 at 10:14 am
(14) Jen says:

Vincent, why is it that so many children and adults for that matter, suffered and their doctors didn’t put 2 and 2 together? Is it because Mercks updated inserts were not metioned to physicians or pharmacists? Why is it that thousands of children have been diagnosed as having mood disorders and been put on Ritalin or some other mood stablizer because of these side effects? It just blows me away. I’ve spoken with numerous child psychologists, physicians, pharmacists, and none of them knew these side effects, and told me that my child could not be experiencing these side effects from Singulair. It wasn’t until I updated them all after my son did a 360 that they started to think. These are some serious side effects that parents need to be warned of.

Can you tell me something? With you being a doctor, I would like to hear from you the importance of leukotrienes in our bodies. This is what singulair blocks, can you explain that to me? There has to be an importance of these, and when they’re blocked it does something chemically, creating this rage in singulair patients.

April 3, 2008 at 2:56 pm
(15) Kathy says:

I am starting to put 2 and 2 together and the timing of my son’s emotional issues correlate very well with the onset of the use of Singulair. He has been taking singulair regurlarly for 7 years. He DID take 3 drug over doses resulting in hospitalization and then being placed in therapeutic boarding school 2 years ago. Of the many doctors, therapists etc. he has seen in the past 7 years, not 1 doctor EVER correlated singulair to his problems. He has been off the drug since March 29 and reports signifcant improvement in his mental status. I think the FDA needs to step up it’s warnings and make sure that EVERY patient is aware of this drug’s possible life altering side effects.

April 3, 2008 at 6:50 pm
(16) crystal says:

im shockd my son has been on singulair for about a year and we went to the dr today and she gve us this information and a new prescrp for a diffrnt drug but now im kind of scared to give my kid anything there have been major changes in my sweet little boy im sad to think it cld have been avoided

April 7, 2008 at 3:05 pm
(17) Misty says:

My son’s side effects are completely opposite of what most are saying. He has the mood swings and acts way out of character (in a bad way) when he DOESN’T take his Singulair. I’ve kept track of his school behavior chart (he’s in kindergarten) and his worse days have been when he’s missed a couple of doses in a row or something like that. When he’s taking it consistently, his behavior is good and he gets the good color :) We’ve began keeping a calendar chart by his medicine to make sure we don’t miss any doses and if we do then we’ll be able to track it. We’ll see.

June 7, 2011 at 8:12 am
(18) ajd says:

Hi Misty, my son appears to be the same.hes nearly 3 and been on singular for 8mths.I took him off it 10days ago & he seems alot unhappier & aggressive.he threw his toys & stones at me because he didnt want to come in. this is very unlike him.. Did you get any confirmation that coming off the singular was the reason for his behaviour??? I rang my gp this morning & getting DS referred to a specialist.

August 4, 2011 at 9:02 pm
(19) Danielle says:

my daughter is 3 and we have taken her off the singulair and she is not her self she throws fits, kicks and screams, for no reason at all she will just start throwing fits.

November 16, 2011 at 12:24 pm
(20) Stephanie says:

I’ve browsed this entire page and your comments are the most recent ones about children experiencing the opposite effects. My 6 year old son has been on & off singulair for about 2 years. Right now he’s been off for about 1 month and his behavior has rapidly deteriorated – at school he has no self-control, does not follow directions, is deliberately defiant and is aggressive to his classmates. This same pattern has happened every other time he has been off the drug. So I’m calling in a refill for him today. But how do I wean him off the drug when I get the worst side effects when he’s not taking it?!

April 8, 2008 at 10:34 am
(21) Marina says:

I have asthma for 20 years and couple years ago my pulmonologist prescribed sigulair to me.
It did not work for me, I started using albuterol way too often, may be because I was on inhaled steroids most of my adult life.
I barely have any asthma symptoms with advair use.

April 21, 2008 at 1:25 pm
(22) jeri says:

During a news broadcast I heard about the potential for singulair to cause suicidal ideation and other harmful side effects. This triggered me to investigate my daughter’s regimen more closely. I believe this medication was causing night terrors which subsequently have stopped since I discontinued this medication for her.

April 22, 2008 at 4:37 pm
(23) mother of a 5-year-old says:

My daughter has been taking Singulair for about 6-months. She has suffered wild mood swings, but we assumed it was the steroids she was taking for her asthma, but after finding out about the issues with Singulair we have taken her off of it. It has only been a few days, so we don’t know what will happen with her moods. What most concerns me is that I only heard about the issues through a friend even though I had taken my daughter to the doctor just a few weeks ago for her mood swings and no one said a word about the drug.

April 27, 2008 at 7:52 am
(24) mother of a 5-year old says:

My son has been on Sungulair for over 2 years and he is still the same sweet, kind, compliant child he always has been. People only report the negative and for the 10 bad comments there are thousands of kids who feel so much better now. Not suffering from chronic sinus infections, headaches, allergy onset of croup, and other upper respiratory infections. We use to have these monthly -no more. New child who is healthy and can play and enjoy life now!

April 27, 2008 at 11:32 am
(25) Susan Sherry says:

I have been on singular for about 3-4 yrs. I have asthma and my Dr. put me on it as a preventative treatment. I have never felt better! I rarely need to take my allergy medicine now due to the use of the singular. I am scared that they will take it off the market! It has helped me feel better about my asthma . I haven’t had but 1-2 asthma attacks in 3-4 years. I am 47 yrs. old and I know this is a pediatrics site but, I think some medications should be studied more for the use of singular and children. Children are more sensitive to many medications. I learned alot when my daughter was diagnosed with ADD and panic disorder. We went through alot of different medicine changes till we got the one that was right for her. Then she was better, and her grades all went up and she said she even liked the way she felt. Not jumping out of her skin anymore. She was in first grade then. She is now 22yrs. old. She is doing great.

April 27, 2008 at 8:10 pm
(26) Detroit says:

My son was on Singulair for 4 years. The years prior to him being on singulair we had countless emergency room visits and bouts with asthma attacks. My child could have been a poster child for singulair as well. But once the symptoms were released this past winter, I too put 2 and 2 together of his side affects. His side effects were headaches every other day, haluciations, mood swings, inattentive and stomach cramps. Although, he never had any suicide thoughts, he did have bouts of depression. I look at photos of my son from the past four years and he never appeared happy even during birthdays and christmas. He always looked depressed. As such, I’ve taken my son off of singulair 3 weeks ago. Thank God he has not had an attack, however, he has complained of not being able to play sports because it’s hard for him to catch his breath. He has not had a single headache and he is smiling more and is attenetive. So I’m looking for other Asthma maintenace such as Advair. Does anyone know of any holistic vitamins or solutions to Asthma care. Please reply Thanks

April 27, 2008 at 9:58 pm
(27) Riga Responder says:

We have had four asthmatic kids on Singulair. It’s a wonderdrug for asthma – just amazing. The weird thing was, they all developed behavioral issues as their asthma got better. This went on for years. Then I started taking it this year, and within 8 weeks I was in a deep depression. I stopped taking it, then I took one kid off of it. The other kids came to me and said, “Why is HE so happy all the time”. Now they are all off it, and our house is so much more peaceful. The effect is very, very dramatic.

I’m trying to figure out how to use the FDA’s Adverse Event reporting system. It’s scary. It’s not clear – it almost sounds as thought if I send the Adverse Event report in, it grants the FDA, and possibly Merck, access to our medical records. There are TWELVE PAGES of instructions. If I were trying to design a system to DISCOURAGE FEEDBACK, this would be it.

So that’s how this drug can be on the market for so long, and the side effects not be reported. And it DOES Work great for asthma. But that’s not worth our sanity.

November 16, 2011 at 10:41 am
(28) SadMom says:

Do you remember how long it took for the side effects to wear off when you stopped the singulair??

April 27, 2008 at 10:41 pm
(29) Vincent Iannelli, MD says:

Iím trying to figure out how to use the FDAís Adverse Event reporting system. Itís scary. Itís not clear – it almost sounds as thought if I send the Adverse Event report in, it grants the FDA, and possibly Merck, access to our medical records. There are TWELVE PAGES of instructions. If I were trying to design a system to DISCOURAGE FEEDBACK, this would be it.

The 12 page ‘Form FDA 3500 – Voluntary Reporting’ includes instructions and the pages your doctor would use to submit a report about adverse effects from a medication to the FDA.

The actual form is only 2 pages and most of it is pretty self explanatory, so you may not even need the instructions for everything. For example, the reports explains how to enter everything from your weight to the date that you filled out the report.

I am pretty sure that you are only granting the FDA and the manufacturer access to whatever records you are sending them. Unless I missed something, you aren’t granting them access to the medical records at your doctor’s office or anything extra. They may follow up with your doctor and ask for more records though.

And it says that everything is kept confidential.

I think the stuff about Health Insurance Portability and Accountability Act (HIPAA) Privacy Rule is so that people understand that it is not against HIPAA rules for doctors to submit a report about a patient’s side effects to the FDA.

June 5, 2008 at 1:24 pm
(30) Mom of 2 on singular says:

Hi All I am a Mom of 2 children on Singular -
One is 8 yrs and the other is 3 yrs.Both have asthma and allergies. Both are sweet kind children but they do have their momoments. My 8 year old is fond lately of saying he hates everyone and hates this family. Does he mean it yes at the time he does but 10 minutes later he wants a kiss from me. Very typical of children of this age especially when they have both older and younger siblings. I also have a 13 year old. People know your children. Know what is age appropriate and what is not. Also, my children are only on the singular during their individual trigger seasons. If your children are taking singular for allergy reasons they should only be on the medication
during those months that trigger thier allergies. They must be tested for what thier allergies are! Stop using pediatricians that prescribe allergy medications without proper testing! And Parents (no offence Dr.Vincent)You have to be your own DOCTOR. ASK QUESTIONS? AND ASK THEM AGAIN AND AGAIN AND OFTEN. LOOK UP INFORMATION THAT YOU ARE GIVEN MAKE SURE THAT IT APPLIES TO YOU OR YOUR CHILDREN. Know why you are being given the medication, how long should you use it, when should you use it and what should you do if you notice behavioral changes,no changes or very little change. Also, allergies and asthma in children can change from year to year? Be aware? Get them tested each year for their allergies and asthma. Just becasue they needed medication (singular) last year at this time means they need it this year even if they have the same symptoms. They could be triggered by somthing different. Also, There are many hoalisticed remedies for allergies, check those out first before get prescribed medications. Very disturbed by what I have read here today.

July 16, 2008 at 2:01 pm
(31) Pepper says:

My son has been on Singulair for 6 years since he was 2 years old…he has been diagnosed with OCD and has radical moods swings and depression. I have never connected it to singulair until I went to this site today. He had a severe meltdown this morning that lasted about 1 hour and I just started investigating whatever I could to try and get to the bottom of this. He was a very calm, easy baby and toddler. He did get frustrated easily, but I think most toddlers go thru that. He has progressively gotten more aggressive and angry especially in the last couple of years. I have sought the help of therapists and my pediatrican, but no one has ever mentioned a problem with singulair. My son has often told me he wants to die and talks about death a lot. This morning after he calmed down from his rage, he had his head on my shoulder and he said, “I just can’t be happy, Momma, I don’t know why.” This is simply heartbreaking! He is NOT going to take singulair anymore. I can only pray that he recovers from these adverse effects like some of the other children I have read about on this site. It scares me that this may have changed who he is for the rest of his life.

August 2, 2008 at 9:40 pm
(32) Rhonda Martin says:

My 5yr old son has been on singulair since he was 2. I recently changed allergists and have an appt with a new one in a few weeks. I was so upset b/c I want my son to stop taking medications! I feel like he’s been taking Zyrtec and Singulair forever. I google searched how long should my child take Singulair and found this site. I just have to say he will not be taking this medicine after tonight! The descriptions above of the mood changes, upset stomach..that is my son. So bad my husband made a comment that he might be bipolar b/c of his mood swings. Happy one second crying the next. He recently went through “hating” everything also. I tried to stop it once in the spring and he had a small asthma attack so I got scared and started him up again..it could have just been that time of year. All I can say is I’m done with it and we’ll just have to look for other options if he starts to have problems. 3 years of this medication is just too long…
Thanks

August 10, 2008 at 1:38 pm
(33) DaveH says:

While some drugs may indeed has side effects, I get so sick and tired (no pun intended) of parents blaming medications for their childrens’ behavior. Perhaps they are behaving the way they are behaving because that’s the way children sometimes behave. Or questionable parenting is causing the children to act the way they’re acting. I am not dismissing the underlying possibility of Singular being at the root cause of a small minority of the complaints, but come on.

May 27, 2011 at 10:56 pm
(34) Janice says:

Yes!! Send your money to this person for You have solved it all!! Those horrible parents!!tsk tsk tsk!! Learn to discipline your child!!(this is sarcasm)

My son (the day the medication was started)had night terrors the entire nightm every night he was medicated. In case you DON”T KNOW what that is, they are “awake” but the brain is “asleep”. they see things that are not there, shake, have accelerated heart rate and sweating. They don’t remember it in the am.
After stopping the drug after a week, he sleeps fine.
But…you might be right. My crappy parenting while he is sleeping must be the case!!

August 10, 2008 at 1:40 pm
(35) DaveH says:

Oops. Typo. I meant “have” in the first sentence, not “has.”

May 21, 2011 at 10:32 am
(36) MJ says:

Wow, I hope you don’t have children and are unable to breed.

August 16, 2008 at 7:10 am
(37) KC Mom says:

Wow, Dave, your ignorance is mind-boggling. My son started having severe OCD symptoms two weeks after taking Singulair. Before that (for the first 9 years of his life), he had no behavioral or mental health problems whatsoever. Now he has had to go on Zoloft and have intense therapy (not covered by insurance). Singulair is EVIL, and I shout that from the hills whenever I get the chance. It should be BANNED. I hope there is a class action resulting from Merck’s CRIMINAL BEHAVIOR in regard to this drug, and I hope the lawsuit bankrupts Merck.

September 2, 2008 at 1:34 pm
(38) sheila says:

I have asthma since I was 14 years old, now I am 30, I did not have much asthma for all these years, and I used Albuterol inhaler when I had an attack, it was smooth going till this May when due to stress I could not control my attacks, so my physician prescribed singulair, and since the day #1, I have noticed bizzare changes, like obsessive compulusive behavior, forgetting often, no interest in life, stomach pain, mood changes, I am completely changed, I have been prescribed this for 3 months, I am really planning to stop this immediately.

September 5, 2008 at 5:51 am
(39) Amanda says:

My daughter is 4 and has been taking singulair for the last 2 months and I thought I had the devil incarnate living in our home. I am the one feeling suicidal by her behaviour, yes she has typical 4 year old tantrums but lately she is very hard to calm down once she gets upset. I am terrified of bringing her out to meet friends because the slightest thing sends her off into a meltdown and he can be violent and uncooperative. I am at the end of my rope thinking I am a bad parent, but I decided to check up if maybe some of her medication was making her so violent. I am taking her off singulair right now, and hopefully we can all return to normal.

September 9, 2008 at 11:49 am
(40) Amy says:

My 8 year old son was put on Singulair about 5 months ago by our family doctor. He was having so many sore throats due to drainage, causing fluid behind his eardrum, etc. caused by allergies. These problems seemed to go away, and I thought this was a great drug for him. However, the new school year has begun, and we have had problems with him daydreaming constantly, unable to pay attention in class. He realizes it himself, and is very frustrated. A.D.D. has been thrown out there, however, he is a very bright kid and learns easily, but couldn’t focus. He was fighting with my other son more frequently, and crying over everything. His self esteem was so low, and it was really worrying me! I had a discussion with his teacher about my concerns, and she was also worried about him. She had asked if he was by chance on this drug, and I was shocked because he was! She had a student the year before that suffered in the same way. They spent a long time investigating, and linked it to Singulair! That is all it took! That night I made him stop taking it! It has not quite been 1 wk yet, but already, we all notice a huge difference, including him. He comes home smiling, goes to bed smiling, and is so happy with himself that he can focus on his work! He is even getting along great with his brother! Needless to say, I will no longer be giving him this drug. I was just thankful someone gave me heads up on this or who knows what the year would have been like. If your child complains of or seems to daydream more than usual, try not giving him/her this drug, and give it a shot. It is worth getting your child back.

September 10, 2008 at 10:20 am
(41) Jan says:

Two years ago our family was going through the same kind of hell that so many of you are reporting – our previously bright and happy son developed terrible anxiety, lost interest in school, said he hated everything, including himself and wanted to die. We considered every cause in the book, questioning our parenting, wondering if he had suffered abuse or trauma unknowingly, or if he was developing OCD or bipolar. A chance comment from my sister about another medication made me wonder about Singulair. ALL OUR DOCTORS ASSURED US IT WAS PERFECTLY SAFE. Only when I found a website with more stories like the ones here did I dare consider taking him off it. Even then I felt unsure, because no medical authority would confirm this was the problem.

Well I’m here to tell you that our son is a whole new person. When I hear him break into giggles watching a funny movie I am so relieved because for awhile there he had completely lost all sense of humor, he was so out of it. Now he can make friends, complete homework assignments, deal with conflict – he can function in the world without freaking out over every little thing! Two years ago, I had lost hope that this would have been possible.

These side effects are a REAL problem – all your stories are the classic Singulair story – I have read hundreds of them now. Stop the drug, get help with behavior therapy, and prepare to be patient, but you will see results. I don’t know what exactly goes on in the brain of those affected, but there is some healing that needs to be done, depending on how old the child and how long they were on the drug. Our son’s mood lifted almost immediately, but he had to relearn a lot of social skills, and the anxiety slowly faded to a garden-variety type (e.g. he still worries about bad weather, but now he just talks about it, rather than act off the wall). I would say he was off the drug for about 9 months when we noticed a more permanent shift, and could truly say that we had our son back.

Also, these side effects don’t always show up immediately. Plus of course children do go through developmental stages, it can be very hard to work out what is a normal tantrum and what is a problem. But I know that those of you who have turned here in desperation KNOW that something is not quite right, and you should trust that. Pay no attention to the nay-sayers who have no business making comments.

I feel so thankful to the parents who came before me and were willing to report their stories online or in the news media. I am frustrated that this story has not really broken out past these blogs. The fact that there are stories here from just last week tells me that we have a lot more work to do to get the word out.

Good luck!

October 21, 2011 at 4:07 pm
(42) Loretta says:

I just found these websites today. My daughter has been on Singulair since she was 3 years old. She is 7 now.
It has seemed that she always has been anxious. In the past 6 months it has ramped up to a new level. She has been worried about thunderstorms 24 hours a day. Now summer is over and she is scared of the rain. All she does is worry. I thought it could be genetic. I have been working on my parenting. I have had her see a therapist and have taken an intervention class. I have considered seeing a therapist. When I read your blog I was stunned by the similarities. Tonight is the first night she will not take it in 4 years. The nurse told me I should see a change immediately so I am surprised you said to be patient and that the anxietyy slowly fades. If you have any more info I would love to hear it. Thanks you for your candor!

September 23, 2008 at 2:05 pm
(43) M.Day says:

My 7 yr old daughter has been on Singulair for about 3 years. We have been frightened by her sadness and talk of hurting herself. I feel her frustration in trying to understand her moods. She can’t articulate how or why she feels this way. We have a very warm and loving family with no trauma or stress going on. We were starting family therapy this week to try to figure this out. I did a search yesterday on the internet to see if anyone had ever reported a connection between any of the allergy or asthma medications that she has taken, and I was sickened by the stories that sound so much like what we are experiencing. I took my daughter off Singulair last night, and she woke up at 4AM with a nightmare, and told me this morning that she had strange dreams all night long. She was a happy giggly girl this morning, despite what I expected to be a sleep deprived child. I know 24 hrs can’t make that much of a difference, but I didn’t tell her why we were taking her off the drug. So that did not influence her mood. Her allergist of course said that there is no evidence of a link with Singulair, but we agreed to switch her to her old prescription of Flovent and see what happens. I so wish our allergist had mentioned that mood swings and depression were something to look out for. It would have saved us all a lot of heartache. For those of you who don’t believe there is a connection, you are not the parents of a child who goes from a happy preschooler to a dark and brooding child. Thank goodness for all the parents who are posting these stories. I hope to report we have our happy child back a month from now.

September 24, 2008 at 10:53 pm
(44) Tracy says:

I saw an allegy/asthma specialist this week for my 19 month old son with severe excema. Has had it since 6 wks of age but broke out in hives a week ago and asked our GP for an allergist referral. He prescribed Singulair chew tabs. Sort of concluded the excema and asthma are linked because I have mild asthma (80% chance he’ll develop it). Has anyone experienced the same situation re: singulair and excema? I haven’t given it to him yet after reading the side effects and warnings and the fact it isn’t recommended for those under 2. I wonder if a little itching is better than the risk of any of the side effects.

September 29, 2008 at 9:34 am
(45) kate says:

If you want to help with the awareness on this drug ,go to medications.com and join the advocacy group.There is a link and it is easy to follow,I for one ,want this drug relabeled and I for one, know how serious the side effects can be.My child was fine mentally and in two weeks he was gone .Suicide was not an end to a long mental illness,it was the lack of disclosure of mood and behavioral changes to look for, while taking this drug that led to his death!!!!!!!

October 9, 2008 at 12:32 pm
(46) ladybug says:

wow, these comments are pretty disturbing. but i do want to add that i’ve been on singulair for over 4 years and have had no issues whatsoever. i’m 43, so that could be the reason. certainly there is a difference between adult and childrens’ bodies and nervous systems, so that could be a big factor. maybe there’s a chance a different or lower dose of singulair will be offered–maybe it’s the dosage itself or concentration of medicine that is off. but so far, no problems at all for me.

i understand that any parent would be concerned, but i also think it’s important to look at the benefits and risks and severity of those side effects. i would definitely be concerned if my young child said he wanted to kill himself, but i’d probably be less concerned if they were having bad dreams. so you have to consider: are edginess and bad dreams worth taking a kid off a drug that could save his life? coz let’s be real–asthma is life-threatening. i’ve known 2 people already that have died from an asthma attack.

some people have mentioned advair, and frankly, THAT is a drug that i would NEVER take. it even wound up on a list of ‘drugs doctors would not take themselves.’ advair has something called a black box warning. basically, the drug was linked to sudden death in a lot of study patients, because of one of the 2 drugs that it contains. that scared me, coz it’s right there in big letters on the box, and in their commercials.

i dunno. i don’t want to defend drug makers necessarily, because i know they’re in business to make money [like every corporation is]. but medicine has its place, and for me, singulair has made my life so much better. i wouldn’t want to take a steroid drug like advair because i read that inhaled steroids are linked to osteoporosis, which runs in my family. maybe i’m wrong.

just one last thing–someone mentioned their child was on singulair and allegra. an allergist put me on that combination, too, and when my regular doctor found out, he got mad and made me switch to zyrtec, because he said the doctor should have known that the combination of singulair and allegra is dangerous. something about a link to irregular heartbeat or some such thing.

i guess we’ll have to wait and see if they find any real link.

October 22, 2008 at 1:13 am
(47) ttruher says:

If you have questions about mental health side effects to singulair, go here: http://www.parentsforsafety.org/17601/index.html

We have stopped singulair for our 5 year old who took it for two years, coincidentally the 2 years we have been struggling with these side effects. We stopped 4 days ago and are seeing many fewer of the problematic behaviors and frustrations and tantrums pass much quicker. He’s becoming the reasonable boy we used to know! Keep your fingers crossed the improvement continues. I am worried about the asthma flare ups since singulair did seem to keep them under control but the mental health of my son tells me to find something different to take.

October 22, 2008 at 2:57 pm
(48) SUMMER says:

my daughter who just turned 3 has had asthma since she was 6 months old. she had be on abuterol and pulmicort for 3 years she was always always sick. she went to the er many times. finally her dr. put her on singular. i cannot say how much it has helped her. she is so much healthier and happier. she can play outside with other kids and no have an asthma attack. I LOVE SINGULAR.

November 19, 2008 at 9:14 pm
(49) Jo says:

Like Tracey, my four year old son has just been prescribed Singulair for Excema. Any parents out there that Singlair has helped for excema/hives alone?

We’ve tried everything. I will be giving my son the Singulair – because I feel there are no other options – his excema/hives/allergies have just got worse the past six months – he is up throughout the night and his behaviour is affected due to the excema/sleep disruption. I’d like to hear if any other parents have children on it, not for asthma but for skin/sinus allergies. Thank you. Jo.

November 24, 2008 at 12:39 am
(50) Lorrie Moylan says:

My 11-year-old son has been taking Singulair since he was 9 years old. At that time he was diagnosed with bronchitis and his pediatrician put him on Singulair. I never questioned him or asked how long he should be on this drug. Looking back now, I can see that my son struggled with mood swings, stomachaches and headaches. It didn’t take much to set him off and he would just walk off and not be able to deal with the normal conflicts in life. About 1 year ago, my son was diagnosed with pneumonia in Dec. and then each month he got sick, sometimes a chest infection and other times sinusitis. I took him off of Advair thinking that may be the problem. He still suffered the mood swings and stomachaches this summer but no major illnesses until Aug. when his Singulair doseage was doubled. He had been taking the 5 mg table once daily and his asthma doctor prescribed the 10 mg tablet because my son could now swallow tablets. Within 5 days, my son got ill and I put him back on the 5 mg tablet. Nov. 1 I decided to put him back on the 10 mg tablet because I didn’t want him to get sick this winter and guess what? On Nov. 4, he was diagnosed with bronchitis. On his asthma doctor’s recommendations, I kept giving him the 10 mg tablet but he started making suicidal comments and finally on Nov.19, I realized that Singulair was causing the suicidal comments and it seems extremely coincidental that my son got so sick a 2nd time after going up to the 10 mg table of Singulair.

I can tell you that after 5 days of having my son off of Singulair, I have a new son. He is happy and he laughs alot and loves to play tricks on people. Before, he was melancholy and didn’t even want to get out of bed. There was even one day when he called me from home and said, “Kill me!” and he hung up. Talk about scary! My son has not made any suicidal comments whatsoever since being taken off of this medicine. I’m so glad that I finally realized what’s causing my son and our entire family so much grief. I just hope that he doesn’t have an asthma attack. Thanks for this website and to everyone who contributes. I hope that my story helps.

March 11, 2009 at 5:31 pm
(51) Sidney W. says:

I have been on Singulair for about three to four years and it works very well for me. Before Singulair, I had tried Theophiline, Tilade, Advair, serovent, and Flovent for my chronic asthma. I like this medication best because it treats my allergy symptoms as well and lessens the effects of my many food allergies. I regret that so many have had such bad side effects with it; however, I hope that it will not be pulled from the market for those of us who do find it to be a blessing. I hope other options will be created for those who need a better one for themselves or their children.

March 15, 2009 at 9:21 pm
(52) Tara says:

I was just put on singular 2 weeks ago, for chronic athsma. Since then I have had the tiredness, muscle aches, and high fever twice. I’m keeping careful watch of my side effects and hope that they improve because my athsma (and use of rescue inhaler) has gotten better since this medication was started.

I have a Ph.D. in pharmacology. What makes me mad is that I specifically asked my MD what the side effects/dangers were . . . and he was like, “none, this medication is totally safe.” I also asked how this medication worked, I specifically asked, “Is this a classical antagonist?” He couldn’t answer my question. If my side effects don’t improve I will definitely let him know and stop the medication.

The bad thing is that there are so many people who don’t even know the right questions to ask. Even if they did I am sure that there are many doctors who prescribe medications every day without the slightest inkling of how they work. You must be proactive about any medicines you are taking and research anything you put into your body thoroughly.

March 15, 2009 at 9:25 pm
(53) Tara says:

LOL. I was just reading the doctor’s bio. I work at UT southwestern in Dallas too. I wish I could find an adult internist as knowledgeable as he is.

April 15, 2009 at 3:58 pm
(54) fanceypants4 says:

i have been on singular for at lest 4 years know i am seeingthe side effects that is me i was in acomma for aweek and a half have hullicinations, crazy dreams even hear things at night laying on my left side. I think i am going crazy sometimes know it is hot my othr meds zoloft seerquel i even went of tem but took singular

April 27, 2009 at 9:14 am
(55) alexx says:

i have now just discovered that i believe this singular is giving my daughter anxiety attacks….there is no question about it.i will be taking her off of this drug asap.

May 21, 2009 at 1:22 am
(56) Concerned Mom says:

Be very concerned about giving your children Singulair. My child took it for several months when he was 9 years old – he became obsessive compulsive – very distinct behavioral changes – he had to wipe down his bed and chair or seat in a car repeatedly before he would sit down or lay – he become obsessive compulsive. I lay in bed trying to find out what was different and it occured to me that it may be the Singulair. I flushed them all down the toilet and within a month or so he was back to normal. I read several posts of parents whose children exhibited agressive or compulsive behavior after taking Singulair. My child was agrumentive and not himself also. Several parents had subsequently put their children on additional drugs to combat these side affects, not realizing that Singulair was the problem. Be very concerned and aware of the possible side effects of this medication. My pediation turned a deaf ear to anything that I told him during and after these discoveries. You need to be looking out for child. The pharmaceutical industry and many physicians are looking only at their bottom line.

May 27, 2009 at 3:44 pm
(57) Roberta says:

My grandson was put on singular and there were immediate changes in his behavior. He started having horrible temper tantrums and after taking his dose at night literally ran around like crazy. He became unreasonable and often displayed violent tendencies. Before this medication while he was a normal two year old displaying normal behavior this medication made him angry and very moody. My grandson’s pulmonologist took him off the medication when my daughter spoke to him of the behavior changes. I’m hoping to soon have my grandson back. Poor baby, no one informed my daughter his mother that there could be negative side effects. You live and you learn but why do our children have to suffer for it.

June 19, 2009 at 9:26 am
(58) Jenna Markle says:

On Friday,June 12, 2009 FDA acknowledged Singulairís neuropsychiatric side effects:agitation, aggression, anxiousness, dream abnormalities and hallucinations, depression, insomnia, irritability, restlessness, suicidal thinking and behavior (including suicide), and tremor. (These side effects have also been reported in connection with Accolate and Zyflo).

The FDA has requested that manufacturers include a precaution in the drug prescribing information (drug labeling).

The FDA advised that, “Patients and healthcare professionals should be aware of the potential for neuropsychiatric events with these medications. Patients should talk with their healthcare providers if these events occur. Healthcare professionals should consider discontinuing these medications if patients develop neuropsychiatric symptoms.”

This is the link to the FDA communication, “Updated Information on Leukotriene Inhibitors: Montelukast (marketed as Singulair), Zafirlukast (marketed as Accolate), and Zileuton (marketed as Zyflo and Zyflo CR)”:
http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/DrugSafetyInformationforHeathcareProfessionals/ucm165489.htm

Comprehensive information about Singulair is available at http://www.parentsforsafety.org.

August 11, 2009 at 2:06 pm
(59) Nicole says:

We’re off Singulair now for three weeks. My daughter is almost three, had been on for two years, and experienced so many side effects that it’s too hard for me to type them.

Tips that work for us in coming off the medicine: treat your child as if they are hypoglycemic. As soon as my two year old gets out of bed in the morning, we give her scrambled eggs or something with protein and very little to no sugar. We continue healthy snacks literally every hour or two throughout the day. As long as she gets enough rest and her blood sugar is not given the opportunity to drop, she is doing MUCH better. This whole issue makes me more upset and sadder than I’ve ever been in my life.

August 12, 2009 at 10:47 am
(60) Jen says:

OK-Im not usually one to jump on the band wagon or jump to believe media hype. My son started taking Singulair about 4 months ago (in the spring) for general allergies and enlarged tonsils and adnoids. The pediatrician who prescibed the medication is an asthma and allergy specialist. At the time she prescibed the medicationm, she mentioned the suicidal hype that was associated with the singulair. She stated that she felt that the information was associated with adults more than with children. She never stated anything about mood swings, behavior problems, etc. I went on my merry way and started giving my son the Singulair. Immediately we noticed an improved difference! However, over the summer, he has become more aggressive and has had huge outburst when he gets angry. He has started hitting, biting, pinching, and scratching when he is angry. I’ve had to pull him of of his 8 year old sister several times (he is 6). His fuse is very short and gets angry over little things. This has not been typical of him in the past–he’s always been very easy going. I’ve always had a few attention concerns so that was not an issue but NEVER any behavior issues. His teachers always say what he’s a very nice boy. Over the summer, I’ve mentioned to my friends that he has become a different child and I am worried about the next school year. What if he has this same outburst at school. He’s on a fast track for a behavior disordered classroom. I know because Im a therapist who works for a school district with kids with special needs! Anyway, after waking up for the 3rd day in a row of him screaming “I hate you, your a dumb fat jerk” to my husband (because he is being disciplined for hitting his sister), a light bulb went off and I thought, “This behavior started at the beginning of the summer around the time we started the Singulair, I wonder if there’s any correlation”? I got on the computer and started researching I found this website (and others). So for the nay sayers, I wasn’t looking for confirmation to a rumor–I never once thought that there might be any connection. I am just at my whits end trying to figure out why my generally happy 6 year old is now acting out so much! Anyway, needless to say, we won’t be taking our nightly dose of medication! Its not worth it!

August 30, 2009 at 11:06 pm
(61) shari says:

i probably cant begin to describe how my daughter was horribly affected by singulair, but i definitely agree with all of the negative effects above. she was put on it at the age of 4 (right around when my motherinlaw passed away)…so i began to think her anxiety, clinginess and strange behavior was that she just didnt want me to leave her. she is now 10…this past year i succumbed to having to drag her into school and became best friends with the nurse and guidance counselor who often saw her in full panic attack mode and heavy breathing…whether she thought she was going to throw up, stop breathing or whatever it was that day. she has had issues with school since preschool..but got worse as the years went on and then one day while we were seeing a therapist she asked if we ever really looked into the side effects of any medicine she takes. so after reading the singulair message boards then i immediately took her off. within a week – i had a new child…which i now cry about and think how often in the past 5 years we fought and i told her how stupid and riduculous she was acting…i wish i would have known…i blamed her for things that werent her fault. but i am now sooo grateful for my little 5th grader who loves her friends, loves school and is always smiling…she goes to her girlfriends houses and doesnt need me to stay with her! i could go on and on…i am so thankful i have her back!!!

September 6, 2009 at 11:24 pm
(62) Concerned mom says:

My husband forgot to give our 3 year old his Singulair yesterday and by the end of the night we were discussing how his behavior was so much better that day. We remembered hearing about “mood swings” and behavior problems as side effects with Singulair and decided not to give it to him today. We can’t believe the change in him! He has been on the drug since he turned 2 and has always been so difficult, exhibiting OCD characteristics and I used to say he was the poster child for ADHD. As an elementary vice principal, I was always perplexed by my son’s behavior and even more so because he was the complete opposite of his twin brother, who does not suffer from asthma or allergies. I am convinced, after all of my research, and seeing the results of my child’s behavior for myself, that Singulair should be pulled from the market! I am so excited to have my son back… and so is his twin brother.

September 14, 2009 at 6:42 pm
(63) Mom to an 11 yr old says:

I am so glad I found this website. My 11 yr old son has been taking Singulair since January of this year. Like other parents on this site, I too kept him on this medicine even throughout the summer months when he was allergy symptom-free. I noticed a small change at first, his arguments with his brother were a little more intense than they had ever been but I attributed it to growing “older.” Well, a few wks ago our allergist recommended he go to a GI doctor to try and figure out why he continues to get croup during the winter months. After this visit, my son became obsessed that there was something wrong with him. School started three weeks ago and he became extremely nervous and it has been a daily struggle to reassure him that he can handle fifth grade. He has always been a straight A, can-handle-anything-that-comes-his-way, never in trouble student. Yesterday, he told me he wished he could be happy again and does not want to worry about everything under the sun. Last night I looked at the Singulair side effects and immediately called his allergist who told us to take him off Singulair today. I am praying that he will revert back to my old, beautiful, funny, happy, loving son very quickly. If it truly is the Singulair that has caused this change in his behavior, then I pray it is something that can be undone without long term harm. Parents that have seen positive changes after removing this drug, thank you for giving me hope.

September 16, 2009 at 10:45 pm
(64) ela says:

my 3 year old boy was on singulaire for a month and boy oh boy the behaviour was over the roof. we could not control him. i was so upset and did not what to do . no discipline worked and i did everything. i read about the change behaviour while on singulaire and is true. i realize naw that all that uncontrolable behavoiur was because of the medication. the doctor put him in singulaire again but after three pills i took him off( when i read about). i dont want to have the same nightmare again. he is a sweet boy and singulaire brings the evil in him. please do not give your child this evil medication

October 21, 2009 at 1:49 am
(65) tammy says:

If you are concerned about Singulair’s mental health side effects, especially in children, please go to this website:
http://www.parentsforsafety.org/17601/10794.html

Also know that many of us are finding that while the worst side effects go away quickly, the aggression side effects linger for potentially years if not forever.

November 30, 2009 at 6:25 pm
(66) Stephanie Hebebrand says:

My son is 9 and has been on Singulair for around 3 years. I have been having behavior problems with him for a long time now and never thought of this. I asked what the long term affect of the drug was and no doctor ever alerted me until just last week. He said we are getting your son off that med. My son suffers from depression, severe mood swings, is all over the place, doesn’t sleep right, gets rashes all the time, and has stomach issues as well. I am curious to see about the behavior. It has only been a week but he has been even more moody than usual. Hope it is the answer.

January 3, 2010 at 7:04 pm
(67) Tina says:

My son started taking Singulair 3 years ago. He had been sleeping in a bed for a full year before this but within a week or so of starting the medication he started falling out so often that we had to put up rails. He also started having nightmares frequently and night terrors and became quite an anxious child. I brought this to the attention of his paediatrician who dismissed it so I continued to give him the Singulair. I was still uncomfortable about giving it to him because at the back of my mind I still felt it was to blame for the nightmares and anxiousness and so I said it to a new pharmacist who opened up in my area and he told me about the FDA investigating the possibility of a link. I took him off it immediatedly. However, I am terrified that it has caused irreparable damage.

January 14, 2010 at 11:34 am
(68) Marjie says:

my 5yr. old daughter has been struggling in the cold season with hacking coughing and sounds like she’s going to choke on her mucus in the night. she’s completely normal in the warm season. doctor put her on singulair this november and it worked! i was lucky not to have any side effects. so she only had 30days of it on 5mg. so this january we asked to put her back on because a few weeks after we stopped it she started again on the mucus choking. but this time the doctor wanted her on 10mg. 10mg!!! are you crazy? she just turned 5!! i decided just to do 5mg since they don’t make 10mg chewables and it’s been helping again. but after looking on the net i’m going to keep a close eye on her. sounds like side effects can start weeks after taking it. thanks everyone for telling your stories. helped me realize to still keep an eye on her even though she looks fine now.

January 27, 2010 at 2:39 pm
(69) HB Mom says:

I am shocked that I am just hearing of these issues. I have 2 boys that have been on Singulair 5 mg for a couple of years. I asked the ID Dr. several months ago about my 6 Year old’s irritability and uncontrollable mood swings, and it was dismissed. He does have asthma and health issues so I chalked it up to him being uncomfortable and not able to explain his pain. Just this past week he has talked about ways to kill himself and how he doesn’t want to be hear anymore. Absolutely HEARTBREAKING. How does a 6 yo understand that?! My 9.5 year old is having severe anxiety and we are being called in to discuss that. They are both off the medication and I sincerely hope this word gets out, because the temporary relief is not worth what it is doing to their precious minds.

February 14, 2010 at 2:35 am
(70) mofmbdc says:

Like Misty (comment # 13) my 8 year old daughter exhibits these horrible side effects when she is off
the singulair. When she runs out of the med she is
aggressive with temper tantrums and huge meltdowns both at school and at home. When we start her back
on the singulair she is much better. I am interested
to see if anyone else has seen this pattern as well.

February 15, 2010 at 3:14 am
(71) Caroline says:

What’s a mother to do? My 4 yr old boy has been hospitalised 3 times in 3 months with Asthma attacks. It’s frightening. This time we started him on Singulair and 1 week in I’m still waiting for him to return to me. He’s completley hyper and when I alerted medics to this, the response always the same ” It’s the high levels of ventalin he’s taken.” However, I simple can’t take the risk of continuing with the Singulair, so Steroids it is – the lesser of 2 evils? Any advice would be appreciated. Thx

March 29, 2010 at 3:40 pm
(72) Tori's Mom says:

My 8 yr old started taking Singulair 4 years ago. She is very anxious about her allergies and asthma. I have always attributed this to our trips to the emergency room due to asthma attacks. Recently, her concerns have turned from anxious to sheer panic. Her heart races and beats so hard you can see it through her clothes. She says she can’t breethe and keeps asking, “am I going to be alright”. Her asthma specialist completely discounts my concerns. I didn’t even know about the FDA early warning until AFTER I started researching correlations between anxiety/heart racing and her medications. She is on Flonase, Singlair, and Asmanex – I have only found the issues we’re experienceing associated with Singulir.
I’m torn now because Singulair has definately improved her asthma and allergy symptoms. I’m truly concerned about stopping the medicine because her asthma was so bad before Singulair. I’m looking for 2nd opinion drs. now.

March 30, 2010 at 11:05 am
(73) Melissa says:

I scares me to think if I don’t give him his preventative, then I am taking that risk of him having an asthma act. However, I went to Singulair’s website to print a coupon and stumbled on the side effect section. My son has been on Singulair since he was 3, he is 6 now. He is extremely intelligent. However he suffers of anxiety, night terrors(dreams that are so real he is petrified!) Little things he overacts to. He has had re occurring ear infections. Which has lead to tubes in his ears. He has been a sickly child and I have done my best to keep him well. However I worry my best efforts have been
tainted all along with this medication. The side effects state… Side effects vary by age and may include headache, ear infection, sore throat, and upper respiratory infection. Behavior and mood-related changes have been reported, including agitation, aggression or anger, bad or vivid dreams, depression, anxiety, hallucinations (seeing things that aren’t there), irritability, restlessness, sleepwalking, suicidal thoughts and actions (including suicide), trembling and trouble sleeping. Need I say more! I can go on and on of my episodes with my beautiful son, that now seem to make since. Trembling over watching a movie he asked to watch. Vivid Dreams of his teacher he loves dearly being a devil. Waking up hallucinating, screaming at me like he just saw a ghost!!! It breaks my heart! I plan to keep writing my sons story everywhere I can from here on out. I don’t want this to be someone else’s family and it end on a bad note. At least I have been given a chance to make things right… So I won’t be using the coupon I printed to pick up the meds today. Very happy to say!!!!!

May 19, 2010 at 11:48 pm
(74) janet says:

What about nearsightedness? My daughter’s sight decreased frequently over the period of years she was on Singulair. Never connected it, but now I read it is an uncommon side affect.

June 20, 2010 at 8:24 pm
(75) outraged says:

I am outraged at the ignorance of doctors that do not report the facts of warnings to patients. THe drug company, did not do a clinical trial looking for these side effects. Parents believe medication approved is safe, that has been proven false, we can look at the facts and documention of past medicines that have been on the market and then pulled. Accutane was another drug, that lead to side mental illness side effects. In the beginning, one may think that was all Hype as well. We have experienced first hand the devestation of this medication.
As parents, we are outraged, with the relationship between doctors and medical marketing, what has happened to advocating for the patient.

July 28, 2010 at 11:26 pm
(76) raiyn says:

My 5 yr old daughter was put on this after an asthma attack in May. I had her on it for about 2 months and EVERY single day she was on it she had these crying meltdown episodes,always over little things that never would have bothered her before. And these episodes were not ‘ I’m not getting my way’ cries…they were truely sad cries that she had a hard time calming down from. I was getting so frustrated , and after reading that this could be a side affect, I stopped the drug (about 3 1/2 weeks ago) and she has not one meltdown since….. Why can’t these drugs just work and not have all these side effects??!

August 17, 2010 at 8:53 pm
(77) joanne says:

My 6 yr. old has been on Singular for 8 months now. He has some mild effects such as moodiness and nail biting along with being a little less confident. But in his case it has been worth it not to see hime suffer ashma attacks which left him much more anxious and afraid to be away from us.We did try at first to start him on it@ 2 1/2 but he was manic! and sleepless. This time as soon as he was having sleep probs we lowered his dose and gave it to him 1/2 in the am and 1/2 in the pm. It helped alot especially with the sleep issue. My girlfirend did the same w/ her son with good results. Children just like adults come in all sizes and have different sensativites. My pediatrican thought I was silly when i explained this but he agreed if it works do it. I also watch the allergy seasons and know my sons “bad seasons”. During the good seasons i cut his dose in 1/2 so that he gets a break but doesn’t get too low. Then if he picks up a cold or ashma trigger of some kind I start him back and use an inhaler for a week or so. Accumilated asthma attacks leave scar tissue so keep trying any combo to prevent these.

September 13, 2010 at 11:44 pm
(78) Nancy says:

I feel badly for the people who’ve had negative experiences with this drug. I’m sure there are a certain percentage who, if studied scientifically, would be found to have a link between use of Singulair and mood swings and other bad side effects.

But another percentage are a combination of sheer coincidence and faulty thinking. I you go on the web you’ll find pages like this with people ranting and raving about how terrible a drug is for every single drug in existence.

This is like when all of a sudden everybody who drove a Prius started getting all hysterical about their break systems, it turned out that most of the break systems were nornal and it was their own bad driving or power of suggestive thinking that was to blame.

I’m not saying AT ALL that there is no merit to any of these claims, but please! People are blaming everything from near-sightedness to eczema on this drug. Guess what? Next thing you know we’ll be dragging out the Bigfoot photos. Perhaps Singulair is the cause for all those witches out there. Burn them!

I have news for all of you. Every single asthma drug ever invented has side effects, many of them severe. If it’s that bad, take your kid (or yourself) off it. It’s not for you, but someone else may benefit. I got a lot of negative side effects from Advair, but I won’t say it’s EVIL; it simply didn’t work for me. (and forget about holistic cures; every holistic healing book I’ve ever read will talk about garlic and onions and cinnamon, but they also say for REAL asthma attacks, you have to take the REAL medicine!

And we certainly don’t want anyone dying of an asthma attack. If I had a choice between a child having mood swings and a child dying because they can’t breathe, I would pick the former.

For God sakes, chemotherapy has bad side effects, but I don’t hear anyone wanting to ban IT. Same goes for polio vaccines, etc. (except for the cranky anti vaccine folks who seem to forget about FDR and the fact that 7000 people die in India every year from polio–)

As a final FYI, my daughter, age 9, has been on Singulair since she was 2 1/2 years old. No negative side effects whatsoever. She’s absolutely the same kid she’s always been. And we frequently take her off it in the summer just for a break, and I can scientificallly tell you that her moods are the same.

I have been on two other asthma meds for years (Symbicort and Spiriva) and still not feeling 100%. My asthma doc (very reputable, cutting edge, wins all sorts of awards) put me on Singulair. I was actually doubtful that it would have any significant effect. Boy, was I in for a surprise. I started feeling better after a week. Perhaps that why my pharmacist of 8 years, also very knowledgeable and reputable, calls it “the wonder drug.” Now I’m breathing great, and guess what. I don’t have eczema, nearsightedness, ADHD, or suicidal depression.

May 21, 2011 at 10:54 am
(79) MJ says:

Are you sure you don’t have any side effects? You seem very ignorant… Maybe you always were.

September 15, 2010 at 8:51 pm
(80) Grover is my Third Child says:

Nancy needs to get off her soap box. I’m glad that your child is doing well. I wish we all could be so lucky…

November 29, 2010 at 2:18 pm
(81) Concerned Mommy says:

My daughter, now 6, has been on singulair since she was like a year old. She has always seemed sad and worried about everything and at times had the “glazed over look”. Her father and I divorced when she was very young and it was not the nicest divorce. We always chalked up her “issues” with the divorce and spent lots of money on therapists who couldn’t find anything wrong or abnormal. Recently, we uped her dosage due to her age and her asthma still not being under control. She startd having some even crazier behavior problems! She was more angry and at times, out of control. She was anxious all the time to the point the school called to talk about it. She seemed more sad than usual and sometimes out of it! She complained of a tummy ache all the time. She was just a different kid, worse than what we had grown “accustomed to”. I heard a story on TV about Singulair and the side effects. I started doing research on it and immediately called the specialist who told me to stop giving it to her. We stopped last Thursday and even in a weeks time noticed a SIGNIFICANT difference in her. I can not imagine how she will feel when all that poison is finally out of her little body! I am disgusted that this medicene is still on the market when it is causing so many problems with our little, innocent kiddos. I can’t imagine what my daughter endured in the 5 years that she was on Singulair. I was NEVER told about any side effects and was never given any other option to treat her asthma except her inhaler, a neb and the Singulair. This medicene should be taken off the market and NOT given to our children…
And to you Nancy, you have obviously not had the experience that most of us have, and I am glad you haven’t and you should feel blessed. Had you had the experiences that we have had you would be singing a much different tune!

December 3, 2010 at 11:53 pm
(82) Raiyn says:

that is what I noticed most with my 5 yr old daughter, too, for the couple months she was on singulair…she often seemed sad and worried ….and she began lacking self esteem…so sad to remember now but i’m sure happy she is off it now!

January 21, 2011 at 6:36 pm
(83) mom of 2 says:

I’m so glad this site exists (still!) my boys took singulair prior to side effects becoming public, couple years ago. People who think this is not for real are simply ignorant. How can you assume to know something when you have not walked in the shoes of all those who have? My doctors also discounted the warnings packaged with the drug. Same question to them. They were clearly wrong. All of this is REAL. I’ve forgotten how bad it was, how clear it was that Singulair was the cause. Was considering putting my asthmatic now- 7-year old back on it to clear his sinuses (yes it worked in many ways) and prevent another infection, but after this reminder, I will not do it. Thanks.

January 26, 2011 at 10:05 pm
(84) Tonya says:

My daughter has been on singulair since she was very young and ever since she started talking she has been a handful. She is 7 now. She throws fits, throws things, screams at me, and has told her dad she wanted to die because everyone was always mad at her. I finally conbvinced him to take her off it as of yesterday so we shall see in the days to come if that has been the issue for the last 5 years. When I asked her doctor about it he just brushed it off like it was no big deal…but because she has been on it since she was 2 1/2 we just thought we had a problem child. I hope that is not the case and it is mostly the Singulair….We will see soon!!! I just want to know….if this is such and issue in children and aldults why the hell they are still making it and giving it to young children!!! I will be exrtemely upset if in three or four days my daughter is a totally different child. I can tell you this much I WILL raise some Hell!!!

February 17, 2011 at 5:29 pm
(85) Lisa says:

Wow, I am shocked, I do not watch television and honestly had no clue about the possible adverse effects singulair could have on a person psychologically. I have been on this medication since it first came out. Not steadily. I am an emergency medical technician and divorced mother of 3. I don’t have much money to pay the co-pays I am charged so I am on and off my medications ( I know that’s very bad for me ). I have never had severe side effects. Migraine headaches which I suffer from anyways and insomnia which again I suffer from anyways. I took this medication while pregnant with all 3 children and all 3 were perfect healthy babies. I am so sorry to everyone who has had an adverse effect. My middle son has asthma like I do and I will honestly say this. If his doctor wants to place him on singulair I will most definitly decline it. Thank you to all who shared their stories and nightmare experiences with this drug. I am grateful I did not have any of those effects listed in previous posts. It’s seems a small blessing to have to readjust to the weeks worth of sleepless nights and headaches while I play idiot with my doses.

February 23, 2011 at 1:41 pm
(86) Toya says:

I have a five year old on Singulair and he dosn’t have the problems that most are talking about. He does have a problem sleeping though. Sometimes he can last all the way till four in the a.m.. He has never expressed feelings of sadness or hurting him self and I just went through a divorce with his father and he is still a happy kid.

February 28, 2011 at 3:12 pm
(87) Veronica says:

The psychological side effects are 100% true. My Husband and I noticed a difference immediatly with my daughter who is 4 and was on it for 2 months. The first month we were unsure but after the second month we stopped immediatly. We will find another way to remedy her allergies. As a parent you have no other choice to stop and seek other avenues after seeing what FDA Approved medication can do to your child. It should be taken off the market.

March 10, 2011 at 3:28 pm
(88) nyparent says:

I am shocked to read all these comments because I relate to all of them that say Singulair is an evil drug. My son has been on Singulair for three months. We have seen a drastic change in his mood, behavior and interest in life. He has no energy, is completely disinterested in most activities now (and was not before) and he is extremely anxious about most basic three year old activities like going to birthday parties or to preschool. It’s true it has probably kept him out of the emergency room for the second time this winter but the side effects are extremely negative. We will be taking him off immediately. I recommend everyone to spread the word. Our pediatrician mentioned no side effects of this drug and assured me it was 100% safe. With all this evidence to the contrary, I find it shocking there isn’t more visibility into these issues.

March 11, 2011 at 9:16 pm
(89) Denise says:

My 5 1/2 year old daughter began taking Singulair a few weeks ago and so far it has worked wonderfully for her. Her constant coughing and chest congestion are finally gone. But because we were afraid of side effects, we’ve been giving her half of the 5mg pill, which works beautifully for her. We had tried Albuterol for months, and then Xopenex, but both made her terribly hyper and made it hard for her to control her behavior, and she had temper tantrums, especially in the late afternoons or evenings. Since beginning the half-dose of Singulair, she’s been so much better! But we will watch her carefully, and take her off the medicine if we see any bad side effects. So sorry to read that so many have had such bad experiences with this drug! We will continue to use it, but cautiously, and only during her worst allergy and cold months.
Best wishes to you all!

April 4, 2011 at 2:32 pm
(90) John says:

I’m 47 years old & been on about every allergy & asthma med out there. I do have problems with side effects which I never had when I was younger. I’m on this web site trying to piece my side effects. I will not condemn any drug. They make them to help. It might not work for all or cause certain problems for some but everyone should look into everything they take.
I’m on advair, singulair, allegra D, Omnaris, Mucinex, & allergy injections. I have had multiple sinus surgeries. I do take Nexium probably to takecare of all the meds I put in. I get along with my Doctor & explain the concerns I have. We joke & have came to conclusion that if I didn’t have these meds & I was a horse….. I would be glue!?!
I was absent from injections twice for 5 years & 2years. I got so bad I have had to be on them since. Inhalers….. 35+ years? I have a nebulizer at home.
I cannot be around any mold.
Your sinuse & lungs are warm & moist…… I have a perfect home for it. I use to be not so sensitve but now???
I live a normal life. Spring is bad when the snow 1st leaves. My home is dry.
My problem is the headaches & lack of energy. I also ran myself down (i play hard) ended up with these viruses?? Viral menningitis, & Pluersy. I have had them before with a weakened immune system & usually this time of year??
Anybody else been on these Meds for years?? I know some names have changed but inhaled steriods through the nose or mouth have been the norm. for decades.

April 12, 2011 at 5:04 pm
(91) Jeanette says:

Thank God! I think I’ve found my answer. My almost eleven year old son has had the worst year. Since starting Singulair last Spring he has been a different child. He has add most everyone of these negitive side effects. I’m throwing out is RX today and praying for a return of my loving,well natured son soon. Thanks to all of you other parents who have been brave enough to pave the way. All of my best to you. Peace.

April 25, 2011 at 1:52 am
(92) GA Daddy says:

My son has only been on Singulair for a week and he’s 11 months old, I have not seen any of the horrible side effects that you are all describing. I am posting to support Nancy from a previous post. Her only issue is her spelling! ; ) She is absolutely right though, if it doesn’t work for you, get off of it!!

April 27, 2011 at 1:10 pm
(93) sabrina says:

wow,so my son has been on singulair for about a year now.since he has been on it he has bad ear infections and had tubes in his ears.he also became very moody and horrible.i cant barely take it no more.his teacher has said he may have adhd.he is 6 years old.i had no idea all this was a side effect.this med is not for him.and from what im reading,its not for many others either.for the few who say its wonderful and no side effects,well thats great for you cause singulair has been working wonders for my sons asthma,i wish we had no side effects.

May 1, 2011 at 9:11 pm
(94) Kim says:

Ive been taking Singulair for about a month now and I read these comments before I started taking it and was really worried. I decided to give it a try anyway. Im 23 years old and I can say I have had NONE of these side effects. A lot of the complaints seem like they are from mothers of young kids on the drug so maybe it effects children differently but the only thing I have experienced is CLEAR breathing, which is something I have not had in a while. Just wanted to let people know that it may not be as bad as everyone says it is!!

May 4, 2011 at 9:42 pm
(95) Harmonia says:

Okay so I was at my doctors office last week. They had some pamplets for allergies and asthma I picked one up and I guess it was for singulair because it had all this information about it, including it’s side effects. I was blown away because I took this medicantion as a young child and do not recall them telling my father about these possible side effects at all and i’m sure even the possibility would have made him ask about other medicines for my asthma. Anyways, that very day my doctor prescribed me this medicine because my asthma has been getting worse. I am also on Loratadine, Verhimist, Patanol (eyedrops) and another medicine called Ranitidine (I think?) for stomatch problems, advair and a xoponex inhalor that I have to take every 4 hours. The Ranitidine and Singulair were prescribed at the same time… I started them on Monday I believe. I am nervous for these side effects but my asthma needs to get better… I have noticed looking at the other complaints… even only taking it for a few days, I haven’t been able to sleep AT ALL. I get very sleepy but toss and turn all night. I also have had problems concentrating. I already have some mild issues with anxiety, panic attacks and depression, i’m wodering if my past with those things will make me more likely to experience side effects? I will say that I am in a very happy place right now starting this medication so if I do experience those symptoms I will assume that it is an effect of the medication. Also, the other medications I take have some of the same side effects like making you shaky and such, does taking multiple medications with the same possible side effects multiply your chances of experiencing those side effects?

May 10, 2011 at 7:18 pm
(96) Nikkii says:

My son is 17 years old, been on singular for about four years or more. In the last two years we have noticed a change in his mood swings and blood and large clots in his urine. He’s had every urine culture, CT scans, scope of his bladder, been to a urologist, onconlogist, and kidney specialist, and nothing has been found. I’m exhuasted with driving 120 miles every other month, two to three times a month just to reach no diagnosis. My husband and I are almost certain that his asthma med is the cause. We mentioned this to his doctor, she didn’t agree. Today is our first day of taking him off the meds ourselves. Hoping for the best. We have spent thousands of dollars trying to get a diagnosis to this problem.

May 12, 2011 at 10:00 am
(97) Mona says:

My daughter has had mood swings and suicidal ideation for some time now – was on singulair as a young child taken off it some years ago but now diagnosed with ocd – anyone have this type of experience years after stopping singulair?

June 10, 2011 at 12:39 pm
(98) D says:

My child experienced severe mood swings on Singular. Never had a problem before, or after. We discontined use after 6 months. Two weeks after we stopped, the mood swings stopped. I took the time to fill out a report for the FDA. More people need to understand that this side effect is possible in young children (my child was 6 at the time, being treated for allergies/asthma).

July 6, 2011 at 10:20 am
(99) floyd says:

My child is 5 years old. He started taking singulair at the age of 2. The side affects were not obvious until he began pre-k. When he entered kidergarten, his mother and I were exhausted because it was a constant battle to get him to go to school. He was aggressive, moody and had a difficult time getting along with other children. We asked his doctor about singulair and he blew us off. We ended up taking him off singulair and saw a drastic change. We have to wonder now if this drug has not caused him some long term affects. We are now in process of seeking furhter medical consultation because even though the affects deminished significantly for him to function, we see some residual things continuing. Anyone with a similar situation please let me know.

July 20, 2011 at 2:08 pm
(100) Disgusted says:

I have relatives who take this drug daily and now they have anger problem, an out of control problem plus physical problemss. They are ages 4, 6 and 8Ö.. the parents are clueless and refuse to listen. After all, their well known pediatrition recommnded it. The kids just need to get control of themselves. It is not the kids faultÖ.itís the drug, parents! A horrible one at that. Take it off the market. Itís dangerous. Parents NEED to wake up! Be your kids advocate. Doctors donít have a clue about the dangerous side effects and donít care. Big Pharma is all about making money not caring one iota about our kids [over 5 Billion in sales annually on this one drug!].

Try Hyland productsÖ homeopathic with NO side effects. They work better than the scripts.

STOP EXPERIMENTING WITH THE CHILDREN!

August 24, 2011 at 12:55 pm
(101) Amy W says:

My 2 1/2 year old son has been on Singulair for 4 months. Recently I have noticed a change in his behavior including crying for little or no reason and aggression towards me and his father when we try to get him to so something he does not want to do (bath, supper, bedtime). I just chalked it up to the “terrible twos” until I got a call from the teacher of his 2-3 year old class. She had too noticed the change and was concerned because he was becoming unmanagable with the other children and causing problems. After I got off the phone I was stunned. Before my child was a sweet, gentle boy who always tried to please. I was racking my brain trying to figure out what I was going to do..then it clicked!! I called the pediatrician and we both agreed to take him off Singulair immediatley. We are now going to try Pulmicort to help ease asthma symptoms. I was told that it could take up to 2 weeks for the Singulair to leave his system. I hope by then I am able to have my sweet boy back!!

September 6, 2011 at 10:15 am
(102) Jamie says:

We 2 children, both girls. Our youngest has had asthma and has been on singular since she was probabably 18 months. She was a very good infant and very easy. She has been a very trying toddler (4 now) and is often out of control. Our first daughter is not at all like this. We have even had other family members talking about her behavior which breaks my heart. I was looking up the side affects of singular and just called her Ped this am. She said that she hasn’t had problems with this before but we will take her off of it and see. Please let me know how it works out with you and we’ll keep our fingers crossed. It makes me sad to think if this has been the problem all the time we could have fixed it before now.

October 28, 2011 at 6:03 pm
(103) E's Mom says:

My son started taking Singulair 9 months ago – and while it does control his asthma, he has starting displaying side effects that are not worth it. He bruises really easily now and is tired all of the time. He is 13 years old and at least once a week comes home from school needing a nap. He also gets skin irritations frequently and has outbreaks of eczema. Our doc ran a battery of tests to rule out autoimmune and blood disorders -everything came back fine. We took him off Singulair and after two weeks, he was a different kid. He looks better, has more energy, and his skin is slowly looking normal. I know that not every child is this sensitive to the medication – but these side effects are too extreme and not worth the trade off to lower his need for his fast acting inhaler!

November 5, 2011 at 2:11 am
(104) Dinah says:

I’m 16 years old.
When I used singulair I was probably 6-10.
After starting the meds, I began constant worrying.
I couldn’t control myself. Thoughts would repeat over and over in my head.
My mom and dad had no idea that the medicine could be doing this to me.
I feel as though this still effects me to this day,
Thanks alot, singulair..

November 16, 2011 at 10:43 am
(105) SadMom says:

My daughter is suffereing from stomache pain, depression & anxiety. The school nurse just showed me the side effects of singulair. I took her off it last night. Does anyone know how long it may take to see changes?

November 23, 2011 at 7:35 pm
(106) Nico's mom says:

I want to thank this site and all the parents for their valuable insight regarding Singulair. My son, age 3 has been on Singulair “powdered form” for 2 years for his allergies. He also has asthma and is treated with albuterol/nebulizer for that. In the last 6 mos my husband and I have received a number of “incident reports” at school regarding his poor behavior. I have also witnessed short attention span. OCD like behavior, refusal to follow directions, hyper and aggressive behaviors as well. It wasn’t until he began hitting his peers and attempting to throw chairs and shout and growl etc…An official parent – teacher meeting took place. The long and short of it is that his behavior is out of control and although we all know that he is on these meds there was a subtle warning that if he didn’t show improvements after some new techniques were implemented he would unfortunately lead to dismissal from the school. Naturally, I panicked! I lost sleep and ran to his pediatrician and allergist. Ironically, both verbalized that there is a link with this medication to severe behavioral disorders…As of now, he is off this med and on with one’s in place nasonex, flovent and ventolin one simply replacing the nebulizer which takes 10 min- praying… for significant changes. Based on what I read here on these posts, I feel confident that these horrid side effects will no longer invade my son’s out of control almost psychopathic tendencies. Yikes! Two thumbs down for Singulair!!! Moms I feel your pain. STAY AWAY!!!

December 2, 2011 at 9:49 pm
(107) Karen says:

Singulair is dangerous! We must do what we can to increase awareness of this scary drug. My 11-year old daughter was on it for 24 days and had severe neuropsychiatric side effects: suicide ideation, nightmares, hallucinations, reckless behavior (ran away from home), severe headaches, depression, fatigue, pain in her joints. She almost got kicked out of school for being a suicide risk. She’s been off of it for 1 month, and things seem to be back to normal. What can we do to raise awareness of this? The doctors don’t seem overly concerned.

December 13, 2011 at 2:10 pm
(108) gina says:

My daughter has been on and off of singulair for a few years. However, over the past 3 months she has been on it consistently. She has allergic asthma. In the past three months, she has developed sleepwaking issues, as well as screaming out in her sleep, hallucinations at night, sever mood swings, outbursts, disrupted sleep at night…and so on. I recently went on the singulair website and surprisingly there they were, all the SERIOUS side effects, just as i listed above. The doctors said they had no idea…oh please, how could you have no idea as a doctor…the pharmacists said yes, and i even called the company that manufactures the drug and they wounldnt speak to me, they said they are not at liberty to speak about this, they asked me if i was a doctor or nurse because then they would speak about it….it is a good drug, it does the trick but no way am i going to let my 6 year old suffer like that….NO WAY

January 13, 2012 at 2:10 pm
(109) Kristen says:

For those of you that took your child off Singulair, what did your pediatrician’s put them on in place of it?

January 20, 2012 at 11:10 am
(110) concerned says:

great input from the parent who’s experienced little ones suffer with these side affects. i’m concerned about giving this to our 6yr old.

February 7, 2012 at 12:14 am
(111) Gin says:

I tend to suspect arificial flavors, colors and sweeteners. This contains all.

My brother grew up with a sensitivity to red dye. His aggressive behavior was directly linked to a red lollipop or popsicle etc… Even as an adult he can feel his mind racing if he has too much. He takes care to avoid it.

I wonder if this is being looked into. Aspartame is not good for anyone. Maybe the drug is safe and the side effects are from the stuff they use to make it pretty and tasty. Give me the real sugar any day.

April 3, 2012 at 10:46 am
(112) bibi says:

my 8 year has been on singular for 4 years. He has severe insomnia, problem with attention at school. He also c/o migraine like headaches.

April 6, 2012 at 7:56 pm
(113) Annie says:

As an herbalist involved in a large community of other herbalists, there ARE natural remedies that DO work. For the person (forgot you name, sorry) who made the comment about garlic and onions…… those help only with mild-moderate infrequent episodes for some; yet people with severe lifelong asthma have been helped with herbs and lifestyle changes. That comment (regarding REAL medicine) is completely false, although unfortunately most people (even many herbalists) believe that herbs are only for minor inconvienences, not serious issues. They are not practicing herbalists trained in traditional herbalism.

Herbs can be the most REAL medicine to someone who has been suffering despite taking all the drugs prescribed by their doctor. Yes, in a crisis, allopathic drugs save lives. There is no question about that but to say it is the only REAL medicine is misguided & untrue.

I can tell you from my own personal experience as well as knowing other herblalists… that it is a very viable option for some people.

Asthma is difficult to treat for many reasons…. especially because the causes are so different from person to person. I have learned to manage my asthma with breath control (www.normalbreathing.com) and herbs, along with essential oils. No more inhaler.

(I must say that I do not do the butyko breathing as described on the normalbreathing.com website. I have personalized a breathing regime that feels right to me and works for me. It is a combination of reduced SLOW diaphramatic nose breathing with no movement of the chest, relaxing all muscles in the body. Within minutes I can regain my breathing. It has been a MIRACLE!!

That may not be suitable for young children but children as young as 5 have learned to manage their asthma this way. Please, please, please never stop searching for answers. There are options but we must not listen to the “authorities” tell us there aren’t.

April 7, 2012 at 3:03 pm
(114) Vincent Iannelli, MD says:

That may not be suitable for young children but children as young as 5 have learned to manage their asthma this way. Please, please, please never stop searching for answers. There are options but we must not listen to the ‚Äúauthorities‚ÄĚ tell us there aren‚Äôt.

If my child has a life-threatening condition, I think I would rather trust would of the “authorities,” rather than someone on the internet posting another MIRACLE cure. Here are what some other people have to say about the miracle, breath control method you describe:

Buteyko Breathing Technique ‚Äď Nothing to Hyperventilate About

April 7, 2012 at 1:11 pm
(115) jean k says:

What is the answer then? Without the singulair, their asthma is horrible.
Is the an alternative med?

April 7, 2012 at 2:46 pm
(116) Vincent Iannelli, MD says:

“What is the answer then? Without the singulair, their asthma is horrible.
Is there an alternative med?”

Keep in mind that most kids who take Singulair don’t have any bad reactions, so if it is working and your kids are doing well, then you should likely just continue it. If they aren’t tolerating Singulair, and needs a preventative medication, then there are plenty of alternative medications to prevent asthma symptoms and flares, including steroid inhalers (Flovent, Pulmicort, Qvar, etc.) and inhalers that combine a steroid with a long acting beta-agonist (Advair, Dulera, Symbicort, etc.).

Also see:

Asthma Inhalers
Controlling Your Child’s Asthma
Hard-to-Control Asthma
Asthma Triggers
Understanding Asthma

April 7, 2012 at 3:08 pm
(117) annie says:

Have these people used the breathing method? Have they experienced it for themselves? I have. It has worked for me. And of course if your child has a life-threatening condition, you make available to them what is most helpful to them. No one is saying to throw away your inhaler or stop your medication. But it is a tool and a very useful one at that to not feel so helpless and out of control. Your comment is an opinion and not based on actual experience. You cannot expect any sane person to take an opinion as expert advice!

April 7, 2012 at 4:25 pm
(118) Vincent Iannelli, MD says:

Your comment is an opinion and not based on actual experience.

My comment includes a link to a very comprehensive article that looked into the technique, complete with a look at available research.

Maybe they don’t consider it expert advice, but unfortunately, many people do put way too much weight into the anecdotal advice and opinions they read on the internet, especially when it is something they want to hear anyway. Because the technique worked for you doesn’t actually mean that it does anything.

April 7, 2012 at 8:05 pm
(119) Annie says:

Oh, you must be right because you have MD next to your name……. It probably didn’t do anything; except completely free me from my inhaler & the terrifying panic and fear that accompanies a severe asthma attack. But I guess because it (my results) wasn’t caused by a drug, it has no value in the medical world. It is just too simple and free. Must be all in my head! Truly….. very sad. I won’t be visiting this site again.

April 18, 2012 at 12:09 pm
(120) Veronica says:

Like Misty in Comment #17 my son’s side effects occur when we have MISSED taking Singulair. My son is 5 years old, about to be 6 in May. He started taking Singulair about a month ago and was fine. It seemed to be helping him with his stuffy nose issues and nasal inflammation. All month he was doing good. Then just this week (after 3 weeks of use) I forgot to give him his pill. That night he woke up saying that he felt bugs crawling all over him, shaking from fear and couldn’t go back to sleep. At first I thought it was just his imagination and dismissed it as such. Then we forgot to give him his pill again and same thing, swearing that he sees bugs on him and trying to flick them off of him! He looked like he was going crazy! Still hadn’t put 2 and 2 together. Then a third night we forgot to give him his pill and it happened again, up almost all night trying to convince him there were no bugs in his bed. He said he could see them! I called his allergist and he said that since it happens when we forget to give him the pill it is not the pill. But I know that it is! I will definitely not give him Singular anymore and will be changing Allergists. Doctors are not aware of all of the side effects! You would think that since it is their field of expertise they would be up to date with all of the possible side effects.
My biggest fear is that since I am taking him off of Singular he will continue to have these hallucinations. Has anyone had the same issues and how long does it take for the hallucinations to completely disappear?

April 19, 2012 at 11:20 pm
(121) Brenda says:

Our son is 11 and has been hospitalized for OCD. He was recently released and we took him to a different asthma/allergy clinic. They immediately told us that he needs to be off the the Singulair. (Replaced with Clairitn.) I came home and am now researching this, and wondering why the psychiatric hospital did not make the connection.

May 8, 2012 at 11:41 pm
(122) Nas says:

Oh my gosh!!

I thank God I found your site. My daughter has been on Singular and Nasonex for months. She is extremely defiant, does not listen, pushes our buttons 24/7 survives on little or no sleep. In addition, she has been complaining of continuous ear aches. We attributed this to the fact that she is prone to ear infections.
On the positive side congnitively it has not affected her at all. She is 3 1/2 at a kidergarten reading/writing level. So I know it has not affected this side. However, in all other aspects there is fighting, screaming and crying all day. It just sprung up a while back and we could never put our finger on it. I will be taking her off singular tonight. I will still need some other medicine for her allergies (we live in Austin: Allergy nightmare).

This is another site I found if it helps:
http://www.medications.com/singulair/browse

Nas

May 8, 2012 at 11:43 pm
(123) Nas says:
May 28, 2012 at 2:00 am
(124) Mom Paris says:

My son is 4 and has been on singular for 2.5 years. I have to say that his asthma was well controlled on singulair. His side effects seemed minimal. He did have some fear of the bath tub at 2.5 years old and a couple nights of night terrors those things are also typical for that age. I would classify him a a type “A’ person. he had several quirks when he was little (small obsession with toy animals, he hated haircuts or dental cleanings, like he was overly sensitive to sensations) but even while on singular, he seems to have outgrown those quirks.

My son is doing so well that after talking to his MD, we decided to take him off os singlair this week. He’s been off 3 nights.

He seems a little grumpy and more impulsive that normal (slightly more aggressive with his sister). Did anyone notice these symptoms more coming off of the drug? He normally has pretty good behavior. I don’t know if he is just tired from our recent vacation or if he is suffering from some sort of withdrawal symptoms.? Any thoughts are appreciated.

May 30, 2012 at 5:50 am
(125) Northwest CT says:

My son has been taking singulair since he was young. He is now 17 and had his first panic attack this year, he read up on singulair and said he feels disconnected and fuzzy.He is tired all the time and seems mildly depressed. An A student athlete I may add. He took himself off singulair last week. We have been to the pediatrician and they dismissed it. Singulair works great for asthma but the long term effects are horrible.

July 1, 2012 at 10:17 pm
(126) Diane says:

My 19 year old son has been on Singulair for many years to treat his asthma. He has always been sensitive and moody but I never linked it to Singulair. During the past 2 years he has been very depressed and was recently diagnosed as bi-polar and OCD. He has been on medication for these as well. Last night his hands were shaking so badly he was unable to write, and so I started investigating all his medications. I was very surprised to see the psychiatric side-effects of Singulair. Now I am wondering if his whole depression/OCD/bipolar is linked to this medication! Now he is on zoloft and geodom for the psychiatric problems and I am wondering if he should even be on those!

October 9, 2012 at 2:56 pm
(127) Anne says:

I was in my 30s when I was put on Singulair; I’ve had asthma since I was a toddler and was on everything from Theophylline to prednisone to Advair, albuterol, and then some. And the ONE medication I will never, ever take again is Singulair. After three days and nights of anxiety, rage, nightmares, paranoia, and hallucinations, I’d had enough. I can’t imagine what it would be like to be a child too young to articulate this medication’s effects. The nightmares were utterly horrific, and the waking thoughts feel evil and disconnected from your soul. I literally thought I was on my way to psychosis. This stuff is crazy-making. If your kid is prescribed it, watch carefully for any changes in behavior. I understand some people have no adverse reactions, but everyone is different.

November 13, 2012 at 2:59 pm
(128) rebecca s. says:

@Diane from July 1, 2012

I hope you read this
Geodon is a very powerful (and in my opinion awful and last choice) medicine given to people with schizophrenia. I know they use it for other disorders as well, but, the possible side effects are horrible.
I suffered from depression on and off for many years, after my son died it pretty much spiraled out of control. When an anti-depressant wasn’t working my doctor kept increasing the dose, then prescribed Seroquel and kept increasing that dose as well. Then I was diagnosed with bipolar 2 (at age 45 with no previous symptomatic experiences). I started suffering panic attacks, paranoia, social anxiety and phobia, became almost a shut in.

I mentioned to the doctors that family members expressed many of my symptoms seemed like ADD to them and he totally dismissed me.

2 years ago I away & started seeing a new psychiatrist, who took me off all antidepressants and other psychiatric meds (slowly) and I was diagnosed with ADHD. I am being treated for the first time in my life for ADHD, on no antidepressants and am functioning better than I have in years. The actions of all the psychiatric medications MADE me exhibit symptoms of bipolar 2, etc.

PLEASE consider having your son weaned off the GEODON etc while under constant supervision, as well as the singulair to see if it helps.

(p.s. DOC, the medication for the ADHD has never affected my sleep, except sometimes wanting to take extra naps and sleep more often-that medication is ruled out)

November 28, 2012 at 10:31 am
(129) MominGA says:

My son started bed-wetting at 8 after being toilet trained at 2. We thought it was school/stress related. It would happen again every spring for a couple of months. He was miserable and ashamed, scared of going on sleepovers and school trips. After reading on a website about a potential Singulair connection, we discontinued Singulair use and bed-wetting stopped. It should be listed as one of the neurological/psychological side effects. It might help many parents and desperate pre-teens.

December 4, 2012 at 3:16 pm
(130) BRENDA says:

I H AVE TAKEN SINGULAIR SINCE 05.IHAVE BEEN TREATED WITH MED. SHOTES FOR HoRRIBLE HORRIBLE PAIN.THIS DRUG RUINT MY LIFE FOR YEARS.I WILL NEVER GET BACK THE YEARS WITH MY HUSBAND OR MY GRANDBABIES. AND YES I AM MAD.I HAVE TAKEN THIS PAPER I HAVE LISTING SIDE EFFECTS TO DIFFERENT DR. AND DRUG STORES.MY GRANDBABYS SIDE EFFECTS BROKE MY HEART. SHE WAS ONLY 3. SHAME ON THEM

December 18, 2012 at 8:19 am
(131) Becky says:

This is a VERY dangerous medication! My son was afflicted with serious murderous thoughts towards his brothers and was scared to death he might actually hurt one of them. DO NOT TAKE THIS MEDICATION! Thankfully those thoughts went away when he was taken off of it and suffers no long term side affects. The warnings for these types of side affects are listed towards the bottom and in small print. What a diservice to the patients not to be told.

January 6, 2013 at 6:24 pm
(132) MumMum says:

My son is nearly 4 and has been taking this medication for only 12 days and the side effects has already started. So YES unfortunately there is something about this medicine that shouldn’t be given to the children. Poor these innocent children who cannot speak for themselves:( `I hate the doctor who prescribed this medication for him. We asked him twice about the side effects, but he only mentioned a couple of not so important ones. In fact his asthma is getting worse and on top of this he is screaming at nights! He has a dosage this evening but now that I have read all these info will stop it for sure.

BUT WE SHOULD TRY TO MAKE OTHERS AWARE OF THIS horrible medicine. It’s awful that some go on for years and then will realise what damage they have done to their angles. I really feel for these kids. a simple allergy will be turned to personality disorder. These days even cancer can be controlled

March 7, 2013 at 11:48 pm
(133) sp says:

Our five year old grandson has been taking Singulair forquite a while and our son and daughter in law has noticed mood changes such as depressive thoughts, things he used to find funny he now finds sad. He is now very fussy something he never was. There was enough signs for them to notice so they called his pediatrician after reading the side effects that came with. His prescription and he and their pharmacist with CVS said they knew of none of those side effects even though they are listed in the script information packet. Someone had better get to the bottom of this fast and stop any pharmacutical cover up. This is extremely serious if it is happening to small pre-schoolers.

March 18, 2013 at 6:36 pm
(134) It affects yound adults too says:

I noticed the past two months I have been feeling fed up, lonely, and just angry at people in general. I initially thought it was just the stress of graduate school. But now that I’ve come to think it, the only thing I’ve done differently these past two months is take singular. I am 24 years old… and sure everyone at this age has their little ups and downs, but I’ve never felt this bad before.

I am going to stop taking this.

March 29, 2013 at 8:28 am
(135) Heidi says:

My son was put on Singulair yesterday. I am having serious second thoughts! I will be calling the Doc and asking some questions of my own. One thing that scares me about all your posts is the fact that you all seem to be quitting this drug cold turkey. I am wondering if weening might be safer, if it takes three weeks to get out of the system and you quit cold turkey, wouldn’t that put the body in some sort of shock? It is obviously a very strong medication that seriously effects the brain, please be very careful!!!

April 23, 2013 at 3:01 pm
(136) beth wales says:

my friend is a support worker in a primary school and recently had time off work.When she returned, she noticed a pupil seemed to have developed twitches ,resembling tourettes-uncontrollable grimacing, muscle spasms and higher levels of anxiety than usual.She spoke to the boys mum, who said he was disruptive and had operations on his eyes for bad conjunctivitis. The child has been on Singulaire for years-since babyhood.His parents gave it to him twice a day for at least 8 years.After noting my friends concerns, the parents looked up side effects of Singulaire and have stopped giving it to him.The result is that he’s happier, ,able to concentrate and the tourettes symptoms have begun to diminish -after only one week.I hope he has no long-term effects from this drug.

April 30, 2013 at 12:09 am
(137) Nelson says:

It was confirmed today that my 2 yr old is severely allergic to Singulair.(It is RARE and this drug does help many people). The past 4 days have been really confusing and scary, especially Saturday night. I am so grateful that I figured this out so soon….People go years putting their kids on all different mood disorder meds, etc and don’t figure this out. They think it’s tantrums or ADD, etc… I couldn’t explain what happened until now. Saturday from 12am-6am: Hallucinations, Psychotic episodes, Self-Harm, Aggressive/uncontrollable behavior, Non-stop screaming, Nightmares, tremors, HORRIBLE experience. Thought I’d share. He is obviously off of it now and last night slept 11 hrs. Now, we are looking for the right answer to help his breathing.

May 1, 2013 at 9:43 am
(138) Diane says:

My 11 year old son took Singulair for about 1 year in 2005 for allergies. He actually did great on it and had no side effects. He has since grown out of the allergies. So now my 7 year old was having horrible spring allergies, so much so that he was waking at 3 or 4am stuffed up and blowing his nose and miserable. We went through every single allergy medicine available over the counter with no real help, so we asked the doc about singular which worked so well for our older son years ago. within a week his allergy symptoms were completely under control. We were so happy . . .UNTIL . . . he went literally from being our sweet loving little boy to a child with angry thoughts and aggression towards us and his siblings, inattentive and depressed in school. Suddenly hating everything including school. He was saying mean and horrible things and also bouncing off the walls. He couldn’t sit still and started rambling incoherently during homework. He started talking to a tree, and finally the last draw was when he told us he wanted to die and wished he was never born.

Now I must say that my son has always had a temper, but his sort of over the top crazy behavior correlated with the start of Singulair. He has not had a meltdown or temper tantrum in a week since his last dose. He doesn’t complain about feeling “hyper”, and last night he sat down and did his homework without jumping out of his seat and arguing with me. It’s like we got our little boy back. If you have seen some of these similar behaviors in your child, I would urge you to consider that Singulair may be the cause. Like I said, my older son did fine on it, but my 7 year old lost his mind on it. Pay very close attention to your child’s behavior, words, and thoughts when he/she is taking this. I am beside myself over the way it effected our 7 year old. It was very scary . . . we thought he was bipolar.

May 20, 2013 at 3:17 am
(139) me says:

Another drug company that should be sued!! To put a drug on the market that is known to cause so many bad side affects!

June 20, 2013 at 1:22 pm
(140) Jack's Mom says:

My son went on Singulair the day he turned 2 years old and immediately, in the 2 days he was on it, he acted like a different child – throwing prolonged screaming fits, hitting others, screaming in anger and crying for long periods of time for no apparent reason. He basically was not acting himself and I suspected it may be related to the medicine so I Googled it and found this site and immediately took him off of it. It’s hard to know with him being on it only 2 days if he was reacting to the medicine or just having a bad couple of days as a 2 year-old but I suspect the former – he was not acting like the wonderful, happy boy he has always been.

August 14, 2013 at 9:55 pm
(141) Carol says:

I am 47 and noticed these irritable thoughts and got really mad at myself last night…and started Singulair just last week. I was worried about the side effects because I’m very drug sensitive. These stories are horrible!

At the same time…everyone who posts here writes very well for a public forum, like they are the same person. All use the same word “sweet” to describe their child before Singulair (not nice or happy). Is About.com making up posts to achieve a higher page ranking??

December 27, 2013 at 1:40 am
(142) Delian says:

Tara – you have a Phd in pharmacology and you’re mad at your doc for not telling you “the dangers” of singulair? Either you attended the worst school known to mankind, you are extremely lackadaisical or just plain lying. And everyone making anecdotal comments about how it messed up their child…kids can moody! they generally become increasingly moody with age. Putting every emotional symptom on a convenient scapegoat is irresponsible and frankly makes you sound a few bricks short of a full load. One wonders if your kids inherited a mood disorder from such a parent.

January 12, 2014 at 2:45 pm
(143) Jeni says:

I have a very important story to share about our very frightening experience with Singulair. My twin daughters were on singular for several years. About a year ago we noticed one normally very happy go lucky daughter was becoming increasingly depressed and having very bad nightmares. I took her to our pediatrician who was very concerned and said to take her off Singulair immediately. Within a week of taking her off, her odd, negative behaviors exploded – severed anxiety, depression, nightmares and mood swings. I did not even recognize my own child. When I called the dr. in a panic he promptly dismissed me and told me she had psychiatric problems. It has been a long, frustrating road of CBT, psychiatrists, testing and even medication. My daughter is a little better, but now has some major struggles with anxiety and even some suicidal thoughts. I can express enough to you all how unusual this is for her – a happy, very social, very bright girl. My heart is broken. Can I prove Singulair caused this? Of course not. I have no scientific research (yet) to back up what I am seeing. I only know something severe happened to my child. I only know the timeline of events. It is everyone’s responsibility to speak up by notifying your dr., Merck, and the FDA if you see any similar reactions to any medication. As soon as my daughter is better, I plan on speaking up more about this, as there is so much more to our story. I would not wish this on anyone’s family. Please beware.

January 12, 2014 at 4:57 pm
(144) Vincent Iannelli, MD says:

I’m glad your daughter is showing signs of improvement and that she is getting help.

Not to say that you shouldn’t <a href=”http://www.fda.gov/safety/medwatch/howtoreport/ucm053074.htm”>report your experiences to the FDA</a> or that it could it be linked to Singulair, but it is also important to note that many children show signs of depression and anxiety for no apparent reason who have never taken Singulair.

January 13, 2014 at 1:28 pm
(145) Jeni says:

Dr. Ianelli,

I think through this whole journey, we have had a trial by fire intro to mental illness We are absolutely open to the idea that these may just be organic, not the cause of any medication side effect. Out only goal now is to figure out how to help out daughter. The only argument I would have is that no Dr. can understand or explain the sudden onset of behaviors. As a mom, I can only rely on my observations and the timeline of events. My daughter went off Singulair and very odd, uncommon behaviors began – in great frequency.
I am happy to see that this issue is starting to be noticed in the medical community. Obviously further research is needed. Hopefully these stories will help us to make more informed decisions about our health care and the medications we take so readily.

February 17, 2014 at 3:35 am
(146) Claire says:

I noticed the difference in my 2 yr old son’s behaviour on day 1 after consuming Singulair. He is not in his usual self, anyhow throw things and tantrums and he cannot sleep well at night, sleep awhile and cry and became angry, irritated, cry easily. It pains me to see him behaving like that.
He cant really express himself yet, but I can see that, he is feeling terrible and he didnt want to be like that. I am going to stop the scary med after 3 feeds out of 7 prescribed dosages.

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